Protein Alignment nAChRalpha7 and Grd

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Alignment Length: 448
• Identity: 91/448 - (20%)
• Similarity: 156/448 - (34%)
• Gaps: 137/448 - (30%)

  Fly    64 LLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWNSSE 128
            ||..||..|::..||... ..|..:...:.:..:..:.|.:.....:.:.:..|.|..|     .
  Fly   112 LLDNLLRGYDNSIRPDFG-GPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRL-----A 170

  Fly   129 FGGVRD---LRIPP-HRLWKPDVLMYNSADEGFDGTYATNVVVR--NNGSCLYVPPGIFKSTCKI 187
            |.|.:|   |.:.. .|:||||...||............|..||  .||..||......|:.|.:
  Fly   171 FEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPM 235

  Fly   188 DITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGG-DISSFITNGEWDLLGVP-GKRNEIYYN- 249
            ::..||.|.|:|.:||||:.|....:..:...|... .|:..:...::||:..| |...:|.|.
  Fly   236 NLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYKA 300

  Fly   250 CCPEPY---------------IDITFA-------------------------------------- 261
            ..|.|.               :..|||
  Fly   301 AAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGLS 365

  Fly   262 ---------------ILIRRKTLYYFFNLIV----PCVLIASMALLGFTLPPD-SGEKLSLGVTI 306
                           :::......:..|.::    ||.|:..::.:.|.|..: :.:::|||:|.
  Fly   366 GTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGITT 430

  Fly   307 LLSLTVFLNMVAET-MPATSDAVPLLGTYFNCIMFMVASSVVSTIL---ILNYHHR--------- 358
            :|::| ||.:.|.| :|..|     ..|..:..:|:....:.:|||   :::|:.:
  Fly   431 VLTMT-FLGLEARTDLPKVS-----YPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFI 489

  Fly   359 -------------NPDTHEM-----SEWIRVIFLYWLPCILRMQRPGQVGYECPPPPS 398
                         .|.|.:.     |:...||.|..  |.:.|          ||||:
  Fly   490 IEELDSESGESETEPLTSDFRGSTESKIYEVIPLSM--CAISM----------PPPPT 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	91/448 (20%)
		Neur_chan_LBD	61..268	CDD:280998	55/280 (20%)
		Neur_chan_memb	275..552	CDD:280999	35/160 (22%)
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	52/219 (24%)
		LIC	111..670	CDD:273305	91/448 (20%)
		Neur_chan_memb	398..667	CDD:280999	35/156 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447315
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030