Protein Alignment nAChRalpha7 and lgc-29

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001317792.1
• Gene: lgc-29 / 3896858
• WormBaseID: WBGene00044528
• Length: 398
• Species: Caenorhabditis elegans
• Alignment Length: 398
• Identity: 84/398 - (21%)
• Similarity: 168/398 - (42%)
• Gaps: 91/398 - (22%)

  Fly    43 VYGLGLLIMIPACAAGP----------------HEKRLLHALLDNYNSLERPVVN-----ESDP- 85
            :|.|...:|:|..:...                |:.||...|..:|:    |.:|     .|.|
 Worm     4 IYSLLFYLMVPLWSTDSQSMTSEQMANYKRFLGHQDRLFEKLFKSYD----PGINAIYTLHSVPE 64

  Fly    86 -------------LQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRI 137
                         :|||. :.|:::::.:||...|..   .:.:|.|..|.|:..::||:..:.:
 Worm    65 TNGTVHPPRFEITIQLSM-MKLVEVVEPEEKATFLFD---YRADWYDTRLSWDPEDYGGINHIYV 125

  Fly   138 PPHRLWKPDVLM---YNSADEGFDGTYATNVVVRNNGSC-LYVPPGIFKSTCKIDITWFPFDDQR 198
            |..::|.|:..:   ::|..:.||..|.....:.:|||. :|: ..:....|::|:..||.|...
 Worm   126 PRSKVWIPETTIVDCFSSEIKVFDNEYTRYAWLHSNGSIGMYI-ASVTSVVCQMDVYKFPMDTHT 189

  Fly   199 CEMKFGSWTYDGFQLDLQLQD-EAGGDISSF------ITNGEWDLLGVPGKRNEIYYNCCPEPYI 256
            |.:.|...||       ||:: ...|...:.      :.||||.:     |..:|.:    ||.:
 Worm   190 CSVNFLFMTY-------QLEEFTIVGKTGTLPRPVEQLGNGEWQM-----KSIQIAF----EPVV 238

  Fly   257 D-----ITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDS-GEKLSLGVTILLSLTVFLN 315
            |     ..|.....|...:|...:::|...|..::::...:..:: .||.::|:|.::|::..|.
 Worm   239 DNLTYLTKFEATFSRNPGFYIVLVMIPAYFINVLSIVALFMDINNRSEKFTVGMTNIMSMSFILV 303

  Fly   316 MVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILI--LNYHHRN---------PDTHEMSE-- 367
            ::||.:|.|.: :|:|..|....:.::..|:.:.:.:  |..::.|         |...|:..
 Worm   304 ILAEDLPKTKN-LPILAIYTVTSLAIMLCSLTAVVALPKLKAYYANRSLARGEKIPKNDEVPRTF 367

  Fly   368 WIRVIFLY 375
            |.|:.|.:
 Worm   368 WERIKFYF 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	80/382 (21%)
		Neur_chan_LBD	61..268	CDD:280998	55/241 (23%)
		Neur_chan_memb	275..552	CDD:280999	23/115 (20%)
lgc-29	NP_001317792.1	LIC	38..>337	CDD:273305	72/324 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010