Protein Alignment nAChRalpha7 and nAChRbeta1

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 535
• Identity: 198/535 - (37%)
• Similarity: 304/535 - (56%)
• Gaps: 59/535 - (11%)

  Fly    42 LVYGLGLLIMIPACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQL 106
            |:..:.:|:.....:|...|:||:..|...||.|.|||.|.:..:.:.|||..:|:|:|:||||:
  Fly     9 LLCSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQI 73

  Fly   107 LITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNG 171
            :.:|:||:|.|.|..|:|:.:::||:..||:||.::||||::::|:||..::..|.:||::...|
  Fly    74 MKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTG 138

  Fly   172 SCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAG-GDISSFITNGEWD 235
            ..|:|||.|::|:|.||:|:||||.|.|.|||||||::|.|:.|.|.:... .|:|.:..:|.||
  Fly   139 EVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWD 203

  Fly   236 LLGVPGKRNEIYYNCCPEP-YIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEK 299
            ::.||...| :|......| ..||||.|:||||||:|..|||:|.|||:.:.:|.|.||.::|||
  Fly   204 IIEVPAYLN-VYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEK 267

  Fly   300 LSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHE 364
            ::||::|||||.|||.:|::.:|.||..:||:..|......|...|::.|::|:|::.|.|.||.
  Fly   268 VTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHR 332

  Fly   365 MSEWIRVIFLYWLPCILRMQRPGQV---------GYECP--PPPSSSSS-------SASGEKKQQ 411
            |..:||.|||::||..|.|:||.:.         |...|  |.||..|.       ||.|.|:.:
  Fly   333 MPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSK 397

  Fly   412 IQNVELKERSSKSLLANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVV 476
            ::.:||.:.                            |.|..  .:.|:.:.|  |.:|    :.
  Fly   398 MEVMELSDL----------------------------HHPNC--KINRKVNSG--GELG----LG 426

  Fly   477 DGRLHEAISHTCLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTL 541
            ||...|:.|...:..|.|...|  .:.:.:|.|.|:.||.......|||:.|||:|||.|.||.:
  Fly   427 DGCRRESESSDSILLSPEASKA--TEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFI 489

  Fly   542 FTIIATLAVLFSAPH 556
            .|...|:.:|..|||
  Fly   490 VTTAGTVGILMDAPH 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	190/508 (37%)
		Neur_chan_LBD	61..268	CDD:280998	91/208 (44%)
		Neur_chan_memb	275..552	CDD:280999	95/294 (32%)
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	194/529 (37%)
		Neur_chan_LBD	28..236	CDD:280998	91/208 (44%)
		Neur_chan_memb	243..498	CDD:280999	95/292 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447312
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940