DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha7 and acr-25

DIOPT Version :9

Sequence 1:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001023570.2	Gene:	acr-25 / 3565563	WormBaseID:	WBGene00043066	Length:	544	Species:	Caenorhabditis elegans

Alignment Length:	531	Identity:	212/531 - (39%)
Similarity:	301/531 - (56%)	Gaps:	52/531 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 EKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWN 125
            |..|...||::|..||||:.|.|:.:.:..||.|.||:|||||||::..|.|||..|.|.:|:|.
Worm    26 EGDLYTELLEDYEPLERPIENSSEAVMVKMGLVLQQIVDVDEKNQVVDVNAWLKFSWVDYSLKWK 90

  Fly   126 SSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGSCLYVPPGIFKSTCKIDIT 190
            ..::|||.|||....:||.||||||||||..||..||:|::|..||...::|||:::.:|||.:.
Worm    91 PEDYGGVTDLRFRKGQLWTPDVLMYNSADPQFDSRYASNLLVYPNGLVNWMPPGLYRLSCKIQVV 155

  Fly   191 WFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGEWDLLGVPGKRNEIYYNCCPEPY 255
            |||||.|.|.:||||||:||.:|:|:: |:.|.|||:::.||||.|.|...|||..||.||||||
Worm   156 WFPFDVQECFLKFGSWTFDGTKLNLEI-DDNGFDISNYMQNGEWTLEGTTVKRNIQYYQCCPEPY 219

  Fly   256 IDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAET 320
            .|:.|..:|||:.|||.||||:||:||..:.|:|||.|||:|||:||.:||:||:.:|.|.|||.
Worm   220 YDLVFTFVIRRRALYYAFNLILPCILITMLTLVGFTFPPDAGEKMSLQITIMLSICIFQNYVAEL 284

  Fly   321 MPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFLYWLPCILRMQR 385
            .|.||:|||.|..:|...:|..|..|.:|.|.||:|||...:|:|:...|::.|.|:|.:|.|:|
Worm   285 SPPTSEAVPFLSAFFAVCLFTCACCVTATTLALNFHHRTGKSHQMNNTFRLLMLEWIPWLLMMRR 349

  Fly   386 PGQVGYECPPPPSSSSSSASGE-KKQQIQNVELKERSSKSLLANVLDIDDDFRCNHRCASATLPH 449
            ||.|. .|            |: .||.....|.:||.::.....:..|...........:.|.|.
Worm   350 PGYVA-RC------------GKIVKQDDSEDEFEERQTRLDQQRIATIISQITVESNKPTPTFPR 401

  Fly   450 QPTYYRTMYRQGDDGSVGPVGPAGPVVDGRLHEAIS--------HTCLTSSAEYELA-------- 498
            :.|....:   ..||......|...|:.....:..|        .|..||......|
Worm   402 RVTIVDEV---NSDGEAEEPLPPDEVIREEDDDVASMDDPPAWRSTTTTSQPPQSPAHLWWNATN 463

  Fly   499 --------------LILKE----LRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTII 545
                          |:|::    |..|.:.:::.:::..|..||||:|:||||:|::|||.|...
Worm   464 RMGNRVPVEQIAQLLVLQQVHGHLSEINKHIREREKSKKIEDDWKFSALVVDRICMVIFTSFLFG 528

  Fly   546 ATLAVLFSAPH 556
            :|:|:..|.|:
Worm   529 STVALFASVPN 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	208/521 (40%)
		Neur_chan_LBD	61..268	CDD:280998	107/206 (52%)
		Neur_chan_memb	275..552	CDD:280999	98/311 (32%)
acr-25	NP_001023570.2	Neur_chan_LBD	26..231	CDD:280998	106/205 (52%)
acr-25	NP_001023570.2	Neur_chan_memb	239..534	CDD:280999	98/310 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3299
OMA	1	1.010	-	-		QHG45242
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.840