Protein Alignment nAChRalpha7 and lgc-28

DIOPT Version :10

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001022053.1
• Gene: lgc-28 / 3565225
• WormBaseID: WBGene00044301
• Length: 397
• Species: Caenorhabditis elegans
• Alignment Length: 308
• Identity: 63/308 - (20%)
• Similarity: 113/308 - (36%)
• Gaps: 67/308 - (21%)

  Fly    86 LQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWK-----P 145
            |||...|.:..|.|:.::..:|...:.....|.|..|.||.|.:.|:|......|.:|:     |
 Worm    56 LQLIPLLHVDHIHDIQDEQGVLKMALTFTFTWMDERLMWNPSNYSGIRTFSTTRHEMWRKKFWTP 120

  Fly   146 DVLMYNSADE----------GFDGTYATNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRC- 199
            .::|.:..:.          ..|...:::.:||.:...:...|      |:.....:|.|.:.|
 Worm   121 TLMMTDVPNSRRPSDVFKPFDMDIYISSSGMVRTSARMMLTIP------CRTGFGSYPNDYKNCT 179

  Fly   200 ----------EMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGEWDLLGVPGKRNEIYYNCCPEP 254
                      :.:|..|  .|.:....|......|:..|      .|:.: ..||  ||......
 Worm   180 FTLMSPYYADQFRFAQW--GGAEFTRYLMSSRVTDVLDF------QLINI-DTRN--YYMFLGSE 233

  Fly   255 YID-------------ITFAILIRRKTLYYFFNLIVPCVLIA-SMALLGFTLPPDSGEKLSLGVT 305
            .:|             ..:.::::|...:....||.|..:|| .:|:.|| ||...|  |....:
 Worm   234 VVDDFSKFKPRHCRSFYRYNLVLKRVNKFVSVQLIAPISVIAVFLAISGF-LPHFYG--LVCAGS 295

  Fly   306 ILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILIL 353
            .|:..|:|...|.:.:|.....:|::.... |.:|      ..||::|
 Worm   296 ALVYETIFTYDVEQVLPKDYSGMPMIAILL-CFLF------AETIVLL 336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	63/308 (20%)
lgc-28	NP_001022053.1	LGIC_ECD	62..>187	CDD:475126	24/130 (18%)
		LIC	67..>329	CDD:455710	55/282 (20%)