DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha7 and nAChRalpha5

DIOPT Version :9

Sequence 1:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	421/531 - (79%)
Similarity:	464/531 - (87%)	Gaps:	21/531 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 MLVYGLGLLIMIPACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQ 105
            :|:|   |.:....|.||.|||||||.|||.||:|||||:|||||||||||||||||||||||||
  Fly   296 LLIY---LNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQ 357

  Fly   106 LLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNN 170
            ||:||:||||||||||||||:|::|||:||||||||:|||||||||||||||||||.||||||||
  Fly   358 LLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNN 422

  Fly   171 GSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGEWD 235
            ||||||||||||||||||||||||||||||||||||||||||||||||||.||||||::.||||:
  Fly   423 GSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWE 487

  Fly   236 LLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKL 300
            |||||||||||||||||||||||||||:|||:|||||||||:|||||||||||||||||||||||
  Fly   488 LLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKL 552

  Fly   301 SLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEM 365
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||
  Fly   553 SLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEM 617

  Fly   366 SEWIRVIFLYWLPCILRMQRPGQ-VGYECPPPPSSSSSSASGEKKQQI-QNVELKERSSKSLLAN 428
            |||||::||.|||.||||.|||: :..|.|..|.|.:||   |:|.|| .:||||||||||||||
  Fly   618 SEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSS---ERKHQILSDVELKERSSKSLLAN 679

  Fly   429 VLDIDDDFRCNHRC----ASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGRLHEAIS-HTC 488
            |||||||||  |.|    ...||||.|.:|||:|.||||||:||:|..      |:.:|:: |||
  Fly   680 VLDIDDDFR--HNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGST------RMPDAVTHHTC 736

  Fly   489 LTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLFS 553
            :.||.||||.|||||:|:||:||:|:||.:||..||||||||||||||||||:|||:||:|||.|
  Fly   737 IKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLS 801

  Fly   554 APHFIVSGVRG 564
            |||.|||...|
  Fly   802 APHIIVSXPYG 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	403/495 (81%)
		Neur_chan_LBD	61..268	CDD:280998	188/206 (91%)
		Neur_chan_memb	275..552	CDD:280999	210/283 (74%)
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	406/499 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444977
Domainoid	1	1.000	288	1.000	Domainoid score	I1532
eggNOG	1	0.900	-	-		E1_KOG3646
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	510	1.000	Inparanoid score	I1280
Isobase	1	0.950	-	0	Normalized mean entropy	S3299
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20350at7147
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	1	1.000	-	-		mtm6506
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3025
SonicParanoid	1	1.000	-	-		X767
	13	12.780