DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha7 and nAChRalpha6

DIOPT Version :9

Sequence 1:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_995675.1	Gene:	nAChRalpha6 / 34304	FlyBaseID:	FBgn0032151	Length:	523	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	348/569 - (61%)
Similarity:	401/569 - (70%)	Gaps:	79/569 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 MSFPQPHSLPEATANGGRMLVYGLGLLIMIPACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQ 87
            |..|.|.||        .:.|..:.|.|:..:| .||||||||:.||..||:|||||.|||:||:
  Fly     1 MDSPLPASL--------SLFVLLIFLAIIKESC-QGPHEKRLLNHLLSTYNTLERPVANESEPLE 56

  Fly    88 LSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNS 152
            :.|||||.||||||||||:|.||.||.|||||.|||||.:|:|||:||||.|::|||||||||||
  Fly    57 VKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNS 121

  Fly   153 ADEGFDGTYATNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQL 217
            |||||||||.||:||::||||||||||||||||||||||||||||.||||||||||||.||||.|
  Fly   122 ADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVL 186

  Fly   218 QDEAGGDISSFITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLI 282
            ..|.|||:|.|||||||.||.:|||:|.|.|.||||||:||||.|.|||:|||||||||||||||
  Fly   187 NSEDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLI 251

  Fly   283 ASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAV------------------- 328
            :|||||||||||||||||:||||||||||||||:|||:||.|||||
  Fly   252 SSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVA 316

  Fly   329 ----------PLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFLYWLPCILRM 383
                      |||||||||||||||||||.|:::||||||..|.|||..||:.:||.|||.||||
  Fly   317 ETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRM 381

  Fly   384 QRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKERSSKSLLANVLDIDDDFRCNHRCASATLP 448
            .|||:       ..:..:...|...|:    :||||||||||||||||||||||  |..:
  Fly   382 GRPGR-------KITRKTILLSNRMKE----LELKERSSKSLLANVLDIDDDFR--HTIS----- 428

  Fly   449 HQPTYYRTMYRQGDDGSVGPVGPAG-PVVDGRLHEAI--SHTCLTSSAEYELALILKELRWITEQ 510
                        |...::|.....| |......|.||  :|.        :|.||||||::||.:
  Fly   429 ------------GSQTAIGSSASFGRPTTVEEHHTAIGCNHK--------DLHLILKELQFITAR 473

  Fly   511 LKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLFSAPHFIV 559
            ::|.|:.:::..|||||||||||.|||:|||||||||:.||.||||.||
  Fly   474 MRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAPHIIV 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	329/520 (63%)
		Neur_chan_LBD	61..268	CDD:280998	161/206 (78%)
		Neur_chan_memb	275..552	CDD:280999	161/308 (52%)
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	337/544 (62%)
nAChRalpha6	NP_995675.1	LGIC_ECD_nAChR	55..236	CDD:349798	142/180 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444978
Domainoid	1	1.000	288	1.000	Domainoid score	I1532
eggNOG	1	0.900	-	-		E1_KOG3646
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	510	1.000	Inparanoid score	I1280
Isobase	1	0.950	-	0	Normalized mean entropy	S3299
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20350at7147
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	1	1.000	-	-		mtm6506
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3025
SonicParanoid	1	1.000	-	-		X767
	13	12.780