Protein Alignment nAChRalpha7 and nAChRalpha6

DIOPT Version :10

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Alignment Length: 569
• Identity: 348/569 - (61%)
• Similarity: 401/569 - (70%)
• Gaps: 79/569 - (13%)

  Fly    23 MSFPQPHSLPEATANGGRMLVYGLGLLIMIPACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQ 87
            |..|.|.||        .:.|..:.|.|:..:| .||||||||:.||..||:|||||.|||:||:
  Fly     1 MDSPLPASL--------SLFVLLIFLAIIKESC-QGPHEKRLLNHLLSTYNTLERPVANESEPLE 56

  Fly    88 LSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNS 152
            :.|||||.||||||||||:|.||.||.|||||.|||||.:|:|||:||||.|::|||||||||||
  Fly    57 VKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNS 121

  Fly   153 ADEGFDGTYATNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQL 217
            |||||||||.||:||::||||||||||||||||||||||||||||.||||||||||||.||||.|
  Fly   122 ADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVL 186

  Fly   218 QDEAGGDISSFITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLI 282
            ..|.|||:|.|||||||.||.:|||:|.|.|.||||||:||||.|.|||:|||||||||||||||
  Fly   187 NSEDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLI 251

  Fly   283 ASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAV------------------- 328
            :|||||||||||||||||:||||||||||||||:|||:||.|||||
  Fly   252 SSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVA 316

  Fly   329 ----------PLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFLYWLPCILRM 383
                      |||||||||||||||||||.|:::||||||..|.|||..||:.:||.|||.||||
  Fly   317 ETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRM 381

  Fly   384 QRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKERSSKSLLANVLDIDDDFRCNHRCASATLP 448
            .|||:       ..:..:...|...|:    :||||||||||||||||||||||  |..:
  Fly   382 GRPGR-------KITRKTILLSNRMKE----LELKERSSKSLLANVLDIDDDFR--HTIS----- 428

  Fly   449 HQPTYYRTMYRQGDDGSVGPVGPAG-PVVDGRLHEAI--SHTCLTSSAEYELALILKELRWITEQ 510
                        |...::|.....| |......|.||  :|.        :|.||||||::||.:
  Fly   429 ------------GSQTAIGSSASFGRPTTVEEHHTAIGCNHK--------DLHLILKELQFITAR 473

  Fly   511 LKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLFSAPHFIV 559
            ::|.|:.:::..|||||||||||.|||:|||||||||:.||.||||.||
  Fly   474 MRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAPHIIV 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	329/520 (63%)
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	337/544 (62%)
		LGIC_ECD_nAChR	55..236	CDD:349798	142/180 (79%)
		Cys-loop	154..168	CDD:349798	13/13 (100%)