Protein Alignment nAChRalpha7 and HTR3A

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_998786.3
• Gene: HTR3A / 3359
• HGNCID: 5297
• Length: 510
• Species: Homo sapiens
• Alignment Length: 563
• Identity: 155/563 - (27%)
• Similarity: 239/563 - (42%)
• Gaps: 124/563 - (22%)

  Fly    48 LLIMIPACAA-----------GPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVD 101
            |.:::|...|           .|...||...||.||....|||.:...|..:|..:.:..|::||
Human    10 LALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVD 74

  Fly   102 EKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVV 166
            ||||:|.|.||.:..|.|..|:||..:|..:..|.||...:|.||:|:....|.| .......|.
Human    75 EKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVG-KSPNIPYVY 138

  Fly   167 VRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSW--TYDGFQLDL-QLQDEAGGDISSF 228
            :|:.|......|....:.|.:||..||||.|.|.:.|.||  |.....:.| :|.::...|.|.|
Human   139 IRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVF 203

  Fly   229 ITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLP 293
            :..|||:||||.....|.... ....|.::.|.::|||:.|:|..:|::|.:.:..|.::||.||
Human   204 MNQGEWELLGVLPYFREFSME-SSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLP 267

  Fly   294 PDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLL--------------------------- 331
            |:|||::|..:|:||..:|||.:|::|:|||:...||:
Human   268 PNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLAS 332

  Fly   332 -----GTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFL---YWLPCILRMQRPGQ 388
                 |.||...|.::..|:..||.|:...|:......:..|:|.:.|   .||.| ||.|...|
Human   333 ALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLC-LREQSTSQ 396

  Fly   389 VGYECPPPPSSSSS-----SASGEKKQQIQNVELKERSSKSLLANVLDIDDDFRCNHRCASATLP 448
                 .||.:|.::     ||.|.....:...:..|:|.:.                ||:....|
Human   397 -----RPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRD----------------RCSPPPPP 440

  Fly   449 HQPTYYRTMYRQGDDGSVGPVGPAGPVVDGRLHEAISHTCLTSSAEYELALILKELRWITEQLKK 513
            .:                                          |...:..:|:||..|.:.|:|
Human   441 RE------------------------------------------ASLAVCGLLQELSSIRQFLEK 463

  Fly   514 EDETSDITRDWKFAAMVVDRLCLIIFTLFTIIA---TLAVLFS 553
            .||..::.|||.....|:|:|...|: |..::|   ||.:|:|
Human   464 RDEIREVARDWLRVGSVLDKLLFHIY-LLAVLAYSITLVMLWS 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	148/534 (28%)
		Neur_chan_LBD	61..268	CDD:280998	72/209 (34%)
		Neur_chan_memb	275..552	CDD:280999	75/319 (24%)
HTR3A	NP_998786.3	LIC	23..504	CDD:273305	150/547 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910