Protein Alignment nAChRalpha7 and nAChRbeta3

DIOPT Version :10

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Alignment Length: 526
• Identity: 118/526 - (22%)
• Similarity: 209/526 - (39%)
• Gaps: 138/526 - (26%)

  Fly    46 LGLLIM----IPACAAGPHEKRL-------LHA-LLDNYNSLERPVVNESDPLQLSFGLTLMQII 98
            :|:|:|    :|...|....|..       ||| |..||:|..:||. :..|..:|..: ::..|
  Fly    24 MGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVF-QGTPTNVSLEM-VVTYI 86

  Fly    99 DVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYA- 162
            |:||.|..|.|:.||.|.|.|....|..|::..:..:.:....:|.|.:.::| .|||  |..|
  Fly    87 DIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFN-GDEG--GLMAE 148

  Fly   163 TNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGG---D 224
            |.|.:.::|...::||.::.:.|::::..:|.|.|.|::|.|||   |.::.|.....|.|   |
  Fly   149 TQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW---GLKVVLPENGTARGESLD 210

  Fly   225 ISSFITNGEWDLLGVPGKRNEI---YYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMA 286
            ....:.:.||::  |..:.:.:   ||.     |::.|  :..:|::..|...:..|...|..:|
  Fly   211 HDDLVQSPEWEI--VDSRAHFVSQDYYG-----YMEYT--LTAQRRSSMYTAVIYTPASCIVILA 266

  Fly   287 LLGFTLPPD-SGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTI 350
            |..|.|||. .|||:.:...:::.:..||...|:.:|..|:..||:..:::..:..::.|.:..:
  Fly   267 LSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEV 331

  Fly   351 LIL----NYHHRNPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSSSSSSASGEKKQQ 411
            |:|    ..|.|.                 ||..||....|.:|........|::..:..||.::
  Fly   332 LVLYLATGKHKRR-----------------LPEALRKLLHGHLGTWLLLSVFSTTGESQAEKTKE 379

  Fly   412 IQNVELKERSSKSLLANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVV 476
                                               :...|      |.:.|:....|:|
  Fly   380 -----------------------------------MDEHP------YEEADEQESSPLG------ 397

  Fly   477 DGRLHEAISHTCLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTL 541
                   |:||.:..:...:.                         ||...|..|||:..:.|:|
  Fly   398 -------INHTEVPGAKANQF-------------------------DWALLATAVDRISFVSFSL 430

  Fly   542 -FTIIA 546
             |.|:|
  Fly   431 AFLILA 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	113/509 (22%)
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:455710	114/511 (22%)