Protein Alignment nAChRalpha7 and Lcch3

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Alignment Length: 426
• Identity: 87/426 - (20%)
• Similarity: 160/426 - (37%)
• Gaps: 110/426 - (25%)

  Fly    46 LGLLIMIPAC-----AAGPHEK--RLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEK 103
            ||..:.:..|     .||..|.  :.:..:|..|:...||... .:||.:...||:.....:.|.
  Fly    18 LGAQLQLIRCIRKDVLAGRLENVTQTISNILQGYDIRLRPNFG-GEPLHVGMDLTIASFDAISEV 81

  Fly   104 NQLLITNIWLKLEWNDMNLRWNSSEFG---------GVRDLRIP----PHRLWKPDVLMYNSADE 155
            |......::|...|.|..|.:|.  ||         |:.|:...    ..::|.||....|..:.
  Fly    82 NMDYTITMYLNQYWRDERLAFNI--FGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNS 144

  Fly   156 GFDGTYATNVVVR--NNGSCLYVPPGI-FKST--CKIDITWFPFDDQRCEMKFGSWTYD------ 209
            ........|.:||  .:|:..|   |: |.:|  |.:|:.::|.|.|.|.::..|:.|.
  Fly   145 FLHDVTERNKLVRLGGDGAVTY---GMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVM 206

  Fly   210 --------GFQLDLQLQDEAGGDISSFITNGEWDLL--GVPGKRNEIYYNCCPEPYIDITFAILI 264
                    |.: |.:|....   |..:.||...:.|  ||               |..::.:..:
  Fly   207 YWKPTPVRGVE-DAELPQFT---IIGYETNDRKERLATGV---------------YQRLSLSFKL 252

  Fly   265 RRKTLYYFFNLIVPCVLIASMALLGFTLPPD-SGEKLSLGVTILLSLTVFLNMVAETMPATSDAV 328
            :|...|:.|...:|.:||..::.:.|.:..: :..:::||:|.:|::|.....|..::|..| .|
  Fly   253 QRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRIS-YV 316

  Fly   329 PLLGTYF-NCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFLYW-----------LPCIL 381
            ..:..|. .|.:|:.|:                    :.|:..|.:.||           ..|.
  Fly   317 KAIDIYLVMCFVFVFAA--------------------LLEYAAVNYTYWGKRAKKKIKKVKECC- 360

  Fly   382 RMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVEL 417
                ||::|     ....|.:.::.|...::|:|.:
  Fly   361 ----PGKIG-----KSERSETCSTTEDIIELQDVRM 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	82/408 (20%)
		Neur_chan_LBD	61..268	CDD:280998	51/242 (21%)
		Neur_chan_memb	275..552	CDD:280999	29/156 (19%)
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	87/426 (20%)
		Neur_chan_LBD	47..256	CDD:280998	50/233 (21%)
		Neur_chan_memb	263..490	CDD:280999	29/156 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447309
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030