Protein Alignment nAChRalpha7 and CG8916

DIOPT Version :10

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Alignment Length: 476
• Identity: 101/476 - (21%)
• Similarity: 185/476 - (38%)
• Gaps: 83/476 - (17%)

  Fly    64 LLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWNSSE 128
            :|..||..|...:.|...:..|..:...:.:..:..|.|.:.....:.:.:..|.|..|.:.
  Fly   111 ILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQYWRDKRLSFK--- 172

  Fly   129 FGGVRDLRIP---PHRLWKPDVLMYNSADEGFDGTYATNVVVR--NNGSCLYVPPGIFKSTCKID 188
             |.::.|.:.   ..::|:||...||............|.::|  .||..||......|:||.::
  Fly   173 -GPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGGILYSMRLTIKATCPME 236

  Fly   189 ITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFI---TNGEWDLLGVPGK-----RNE 245
            :..||.|.|.|.:..||:.|...||..:.:::  .|..||:   |..::||:.:..:     |.|
  Fly   237 LQNFPMDRQSCPLVIGSYGYINQQLIYEWKNQ--DDAVSFVPGMTLNQFDLISMMHRNFTTVRRE 299

  Fly   246 IYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPD-SGEKLSLGVTILLS 309
            ..::.       :..|..::|.|.|:...:.|||:||..::.:.|.:..: :.:::||.||.:|:
  Fly   300 GDFSV-------LHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDRVSLCVTSVLT 357

  Fly   310 L-TVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTIL-ILNYHH-------RNPDTHEM 365
            | |:.|:...: :|....|..|  .:|..:.|:..   ::|:| ....|:       .:|...:.
  Fly   358 LSTISLDSRTD-LPKVKYATAL--DWFLLMSFLYC---IATLLEFAGVHYFTKLGSGESPQLEDQ 416

  Fly   366 SEWIRVIFLYWLPCILR--MQRPGQV--GYECPPPPSSSSSSASGEKKQQIQNVELKERSSKSLL 426
            .|.|         ||..  ....|:|  ..|....|.:...|::|.:....:....:...|||.:
  Fly   417 WEDI---------CIANSLSDHAGEVDGDGEADADPFADEDSSNGSENDDNEAGASESVESKSGV 472

  Fly   427 A-----NVLDIDDDFRCNHRCASATLPHQ-----PTYY-------RTMYRQGDDGSVGPVGPAGP 474
            .     :.|.::.:....:..|.|....:     |||.       .||.|         .....|
  Fly   473 CVCNKNDALGLEYEVSLQNSLAGAGFLKRNAIFCPTYNDPSYILPNTMER---------TTQTEP 528

  Fly   475 VVDGRLHEAISHTCLTSSAEY 495
            ....|||:  ...||.|...:
  Fly   529 PAVSRLHQ--MWMCLKSDNSF 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	101/476 (21%)
CG8916	NP_573090.3	LIC	92..598	CDD:455710	101/476 (21%)
		LGIC_ECD_GABAR_GRD-like	132..314	CDD:349808	41/194 (21%)
		Cys-loop	233..247	CDD:349808	5/13 (38%)