DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha7 and nAChRalpha3

DIOPT Version :9

Sequence 1:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster

Alignment Length:	764	Identity:	229/764 - (29%)
Similarity:	325/764 - (42%)	Gaps:	267/764 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LLIMIPACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIW 112
            :|..|.:..|.|..|||...||.|||.|.|||||.:|.|.:...|.|.|:|||:.|||::.||:|
  Fly    13 VLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLW 77

  Fly   113 LKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGSCLYVP 177
            ::..|.|..|:|...|:|||..|.:|...:|:||:::||:||..|:.|.||...:...|...:.|
  Fly    78 VEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRP 142

  Fly   178 PGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGG--------DISSFITNGEW 234
            |.|:||:|:||:.:||||:|.|.||||||||||||:||:..||..|        |:|.|.|:.||
  Fly   143 PAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEW 207

  Fly   235 DLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEK 299
            |:|.||..|||.:|.||.|||:||||.|.:|||||:|..|||:||:.|:.:.:|.|.||.|||||
  Fly   208 DILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEK 272

  Fly   300 LSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHE 364
            :||.::||||||||..::||.:|.||..|||||.:....|.:...|:..|:|:||.|.|:|.||.
  Fly   273 VSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHT 337

  Fly   365 MSEWIRVIFLYWLPCILRMQRP----GQV-------------GYE-------CPPP--------- 396
            |:.|:|.:|:..||..|.|:||    .::             |.|       .|||
  Fly   338 MAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMHHS 402

  Fly   397 PSSSSSSASGEKKQQIQNVEL-------------------------------KERSSKSLLANVL 430
            |.::|.|.|...:.::|...|                               ::.|:.|.|
  Fly   403 PKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQTSTTSSL---- 463

  Fly   431 DIDDDFRCNHRCASATL---PHQPTYYRTM--------------------------------YRQ 460
             ||..:...::....:|   |..||.:|.|                                |||
  Fly   464 -IDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSGGHHLYRQ 527

  Fly   461 ------------------------GDDGSVGP-----------VGPAGPVVDG------RLHEAI 484
                                    .|.|...|           |..|..:.|.      ::|:.:
  Fly   528 QSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGTIQIHQGM 592

  Fly   485 S---------------------------------------------------------------- 485
            .
  Fly   593 GAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSAAAAAA 657

  Fly   486 --------------------------------------------HTCLTSSAEYELALILKELRW 506
                                                        |||      .||...:..:.:
  Fly   658 AAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTC------PELHKAMDGVTY 716

  Fly   507 ITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLFSAP 555
            |.:|.:||:|::.:..|||:.|||:|||.|.|||:..::.|..::..||
  Fly   717 IADQTRKEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIILQAP 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	223/744 (30%)
		Neur_chan_LBD	61..268	CDD:280998	107/214 (50%)
		Neur_chan_memb	275..552	CDD:280999	111/524 (21%)
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	107/214 (50%)
		Neur_chan_memb	248..>359	CDD:280999	53/110 (48%)
		Neur_chan_memb	<683..760	CDD:280999	24/82 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447300
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940