Protein Alignment nAChRalpha7 and chrnb3b

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_775394.1
• Gene: chrnb3b / 317643
• ZFINID: ZDB-GENE-030102-4
• Length: 462
• Species: Danio rerio
• Alignment Length: 509
• Identity: 177/509 - (34%)
• Similarity: 268/509 - (52%)
• Gaps: 93/509 - (18%)

  Fly    61 EKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWN 125
            |..||..|...|....||:::.:..:::.|||.:.|::||||||||:.||:||..||.|..||||
Zfish    31 EDALLRDLFQGYQRWVRPILHANHTVKVRFGLKISQLVDVDEKNQLMTTNVWLYEEWLDYKLRWN 95

  Fly   126 SSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGSCLYVPPGIFKSTCKIDIT 190
            ...:||:..:|:|...:|.||:::|.:||..|:|:..|..:||.||...:.||..:||.|.:|:|
Zfish    96 PENYGGITFIRVPSESIWLPDIVLYENADGRFEGSIMTKAIVRYNGLITWTPPASYKSACTMDVT 160

  Fly   191 WFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGEWDLL---GVPGKRNEIYYNCCP 252
            :||||.|.|.||||||||||..::|.|.:.. .|.|.|..||||::|   |..|.|.:.:|:
Zfish   161 FFPFDRQNCSMKFGSWTYDGNMVELVLVNHQ-VDRSDFFDNGEWEILSATGHKGSRRDGHYS--- 221

  Fly   253 EPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMV 317
            .||  ||::.:::|..|:|...||:||:.::.:.:|.|.||.|.|||:||..::|:||||||.::
Zfish   222 YPY--ITYSFILKRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKVSLSTSVLVSLTVFLLVI 284

  Fly   318 AETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDT-HEMSEWIRVIFLYWLPCIL 381
            .|.:|::|..:||:|.|...||..|..|::.|:.::|.|||:..| |.||.|:|.:||..||.:|
Zfish   285 EEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSATYHPMSPWVRTLFLQRLPDLL 349

  Fly   382 RMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKERSSKSLLANVLDIDDDFRCNHRCASAT 446
            .| |.....|..|              :.:.|:.:||.||.|
Zfish   350 CM-RGNTDRYHYP--------------QMEPQSPDLKPRSKK----------------------- 376

  Fly   447 LPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGR-----LHEAISHTCLTSSAEYELALILKELRW 506
                                   ||.||..||:     |.:|      |:|           :|:
Zfish   377 -----------------------GPPGPEGDGQALINMLEQA------TNS-----------VRY 401

  Fly   507 ITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLFSAPHFIVS 560
            |:..:|||....::.:||||.|.|:||:.|..|...:::.|:.:...|....:|
Zfish   402 ISRHIKKEHFIREVVQDWKFVAQVLDRIFLWAFLTVSVLGTILIFTPAVKMFLS 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	174/495 (35%)
		Neur_chan_LBD	61..268	CDD:280998	89/209 (43%)
		Neur_chan_memb	275..552	CDD:280999	84/282 (30%)
chrnb3b	NP_775394.1	LIC	5..449	CDD:273305	175/501 (35%)
		Neur_chan_LBD	31..235	CDD:280998	89/209 (43%)
		Neur_chan_memb	242..446	CDD:280999	84/281 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910