Protein Alignment nAChRalpha7 and CG6927

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_572194.1
• Gene: CG6927 / 31419
• FlyBaseID: FBgn0029733
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 588
• Identity: 116/588 - (19%)
• Similarity: 195/588 - (33%)
• Gaps: 216/588 - (36%)

  Fly    63 RLLHALLDNYNSLERPVVNESDPLQLSFGLTL------MQIIDVDEKNQLLITNIWLKLEWNDMN 121
            ||.|..  .|:.||||:.......:|...:.:      ||.::..:    |...|:..|:...::
  Fly    42 RLTHGC--RYDRLERPITYSETGQRLPVDVYMRAYIYFMQNLEAHD----LQFKIYALLQMRYLD 100

  Fly   122 LRWNSSEFGGVRDLRIPP--------HRLWKPDVLMYNSADEGF--------------DGTYATN 164
            .|.|   |..|...|..|        :.||.|.:.:.|..|...              |||
  Fly   101 PRLN---FRNVSPKRRQPILGEEHLRNSLWMPHIFLANERDSSILGLTEKDILTSISPDGT---- 158

  Fly   165 VVVRNNGSCLYVPPGIFKST--CKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQD------EA 221
            |:|.|.          .|:|  |.:::..||||:|.|.....||.|:..:|.|..:.      :.
  Fly   159 VIVSNR----------IKATLYCWLNLKKFPFDEQHCSTVLESWMYNTSELVLHWEQKRPITYDG 213

  Fly   222 GGDISSFITNGEW--------DLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVP 278
            ...::.|:....|        ||       :::.:......|..::|.:.:.|...:|..:..:|
  Fly   214 ALHLTEFVLQRSWSNETVINADL-------SDLRHGAFAGNYSSLSFTVHLTRVVGFYLMDYFLP 271

  Fly   279 CVLIASMALLGFTLPPDSG-EKLSLGVTILLSLTVFLNMVAETMPATS----DAVPLLGTYFNCI 338
            .:||.:::.:.|.|..|.. .:::||.:.||:.....:...:|:|..|    ..|..||    |.
  Fly   272 SMLIVAISWVSFWLQADQAPPRITLGTSTLLTFITLASAQGKTLPKVSYIKVSEVWFLG----CT 332

  Fly   339 MFMVASSV----VSTILILNYHHRNPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSS 399
            :|:..|.|    |:||                 |.|
  Fly   333 IFIFGSMVEFAFVNTI-----------------WRR----------------------------- 351

  Fly   400 SSSSASGEKKQQIQNVELKERSSKSLLANVLDIDDDFRCNH---RCASATLPHQPTYYRTMYRQG 461
                    ||    :|.:|:.:||.:|.:.|..:...|.:|   |..|.|         .:::..
  Fly   352 --------KK----SVPVKKLNSKHILKSTLSPNLLRRRSHARSRSFSGT---------ALHKTA 395

  Fly   462 DDGSVGPVG--------------PAGPVVD-----------------------------GRLHEA 483
            |.||:|..|              ..|.|:|                             |.:..|
  Fly   396 DTGSLGGAGFNNYLTVNLPITTIKEGQVLDQQRTSRVVQKMDVNFVESAFGSMGSAQSTGAISAA 460

  Fly   484 ISHTCLTSSAEYELALILKEL---RWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTII 545
            .|...||::...|.|...:|:   .|.|  |..::           .||.:|.....:|.|..::
  Fly   461 SSSQTLTNNNRTESAGHQEEIDLSGWTT--LTPQE-----------IAMWIDSRARFVFPLSFLV 512

  Fly   546 ATL 548
            ..|
  Fly   513 FNL 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	115/586 (20%)
		Neur_chan_LBD	61..268	CDD:280998	52/248 (21%)
		Neur_chan_memb	275..552	CDD:280999	63/332 (19%)
CG6927	NP_572194.1	LIC	3..520	CDD:273305	116/588 (20%)
		Neur_chan_LBD	36..259	CDD:280998	51/246 (21%)
		Neur_chan_memb	270..518	CDD:280999	63/330 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447261
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030