Protein Alignment nAChRalpha7 and Chrne

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_017452660.1
• Gene: Chrne / 29422
• RGDID: 2353
• Length: 547
• Species: Rattus norvegicus
• Alignment Length: 570
• Identity: 158/570 - (27%)
• Similarity: 268/570 - (47%)
• Gaps: 100/570 - (17%)

  Fly    13 SCPGQDRTRSMSFPQPHSLPEATANGGRMLVYGLGLLIMIPAC-------------AAGPHEK-R 63
            |.||        :||.|..|..:|:      ..|||.:.|...             :.|.:|: .
  Rat    29 SIPG--------WPQTHRDPPVSAS------CVLGLKVYITDAWHCDHHGEKQTGRSQGKNEELS 79

  Fly    64 LLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWNSSE 128
            |.|.|.|||:...|||....|.:.::..:||..:|.::||.:.|.|::|:.:||.|..|.::..:
  Rat    80 LYHHLFDNYDPECRPVRRPEDTVTITLKVTLTNLISLNEKEETLTTSVWIGIEWQDYRLNFSKDD 144

  Fly   129 FGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGSCLYVPPGIFKSTCKIDITWFP 193
            |.||..||:|...:|.|::::.|:.|..|...|..||:|...||..::||.|::|||.:::|:||
  Rat   145 FAGVEILRVPSEHVWLPEIVLENNIDGQFGVAYDCNVLVYEGGSVSWLPPAIYRSTCAVEVTYFP 209

  Fly   194 FDDQRCEMKFGSWTYDGFQLD--LQLQDEAGG------DISSFITNGEWDLLGVPGKRNEIYYNC 250
            ||.|.|.:.|.|.||:..:::  ..:.|:...      |.::|..||||.:...||.........
  Rat   210 FDWQNCSLIFRSQTYNAEEVEFIFAVDDDGNAINKIDIDTAAFTENGEWAIDYCPGMIRHYEGGS 274

  Fly   251 CPEP-YIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDS-GEKLSLGVTILLSLTVF 313
            ..:| ..|:.:.::||||.|:|..|:|||||||:.:.||.:.||..: |:|.::.:.:||:.|||
  Rat   275 TEDPGETDVIYTLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVF 339

  Fly   314 LNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFLYWLP 378
            |.::|:.:|.||.:|||||.|...:|.:....|::.:::||...|.|.||..|..:|.|.|..||
  Rat   340 LFLIAQKIPETSLSVPLLGRYLIFVMVVATLIVMNCVIVLNVSLRTPTTHATSPRLRQILLELLP 404

  Fly   379 CILRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKERSSKSLLANVLDIDDDFRCNHRCA 443
            .:|.:.         |||....::|.:    ::..:|.:..|:.:.:|..
  Rat   405 RLLGLS---------PPPEDPGAASPA----RRASSVGILLRAEELILKK--------------- 441

  Fly   444 SATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVV-DGRLHEAISHTCLT-----SSAEYELALILK 502
                                       |...:| :|:.|...:.|...     |:|..|:...:.
  Rat   442 ---------------------------PRSELVFEGQRHRHGTWTAAALCQNLSAAAPEVRCCVD 479

  Fly   503 ELRWITEQLKKEDETSDITRDWKFAAMVVDRLCL-IIFTLFTIIATLAVL 551
            .:.::.|..:.::.|.:...||......:|.:|. ....||::.:||..|
  Rat   480 AVNFVAESTRDQEATGEELSDWVRMGKALDNVCFWAALVLFSVGSTLIFL 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	142/506 (28%)
		Neur_chan_LBD	61..268	CDD:280998	71/216 (33%)
		Neur_chan_memb	275..552	CDD:280999	70/285 (25%)
Chrne	XP_017452660.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910