Protein Alignment nAChRalpha7 and HTR3E

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001243543.1
• Gene: HTR3E / 285242
• HGNCID: 24005
• Length: 482
• Species: Homo sapiens
• Alignment Length: 396
• Identity: 103/396 - (26%)
• Similarity: 162/396 - (40%)
• Gaps: 69/396 - (17%)

  Fly    41 MLVYGLGLLIMIPACAAGPH--EKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEK 103
            |...|.|:...|.....|.|  :...|:::.:  ....|||.|.|.|.|::....:..|:||
Human    34 MSTTGRGVTFTINCSGFGQHGADPTALNSVFN--RKPFRPVTNISVPTQVNISFAMSAILDV--- 93

  Fly   104 NQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYN----------------- 151
                        .|::..:.||..|..|:..:.:....||.||:.:..
Human    94 ------------VWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELCVSRAGQREVPSPGSH 146

  Fly   152 -----------SADEGFDGTYATNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGS 205
                       ..|:...|..|   .|.|.|...|..|....|.|.:||.:||||.|.|.:.|.|
Human   147 RDHSLPLGPLMDVDKTPKGLTA---YVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSS 208

  Fly   206 WTY--DGFQLDLQLQDEAGGDISSFI--TNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRR 266
            :.|  |...||::.:.....|.|..|  |:|||:|||:.....::...  ...|..|.|.:.|||
Human   209 FLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRG--GNLYDQIVFYVAIRR 271

  Fly   267 KTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLL 331
            :...|..||:||...:.::..|.|.||..||.::...:|:||...|||.|:::.:|  :...||:
Human   272 RPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLP--TSGTPLI 334

  Fly   332 GTYFNCIMFMVASSVVSTILILN-YHHRNPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECPP 395
            |.||...:.::..|::.||.|.: .|........:..|:..:.|:   |    ..||:.   ||.
Human   335 GVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLH---C----NSPGRC---CPT 389

  Fly   396 PPSSSS 401
            .|...:
Human   390 APQKEN 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	98/378 (26%)
		Neur_chan_LBD	61..268	CDD:280998	60/238 (25%)
		Neur_chan_memb	275..552	CDD:280999	35/128 (27%)
HTR3E	NP_001243543.1	Neur_chan_LBD	70..273	CDD:280998	59/222 (27%)
		Neur_chan_memb	280..>379	CDD:280999	28/100 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910