Protein Alignment nAChRalpha7 and Chrna4

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_038960311.1
• Gene: Chrna4 / 25590
• RGDID: 2346
• Length: 802
• Species: Rattus norvegicus
• Alignment Length: 665
• Identity: 213/665 - (32%)
• Similarity: 315/665 - (47%)
• Gaps: 149/665 - (22%)

  Fly    18 DRTRSMSFPQPHSLPEATAN--GG-----------RMLVYGLGLLIMIPACAAGPH-------EK 62
            :|.|..:..:|...|...|.  ||           .:|:.|.|||      .|..|       |:
  Rat   142 ERRRGTAGSRPRLEPARCAMEIGGPGAPPPLLLLPLLLLLGTGLL------PASSHIETRAHAEE 200

  Fly    63 RLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWNSS 127
            |||..|...||...|||.|.||.:.:.|||::.|:||||||||::.||:|:|.||:|..|||:..
  Rat   201 RLLKRLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPG 265

  Fly   128 EFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGSCLYVPPGIFKSTCKIDITWF 192
            ::..|..:|||...:|:||:::||:||..|..|:.|...:..:|...:.||.|:||:|.||:|:|
  Rat   266 DYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTPPAIYKSSCSIDVTFF 330

  Fly   193 PFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGEWDLLGVPGKRNEIYYNCCPEPYID 257
            |||.|.|.|||||||||..::|| :...:..|...|..:|||.::...|..|...|.||.|.|.|
  Rat   331 PFDQQNCTMKFGSWTYDKAKIDL-VSMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPD 394

  Fly   258 ITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMP 322
            ||:|.:|||..|:|..|||:||:||:.:.:|.|.||.:.|||::|.:::||||||||.::.|.:|
  Rat   395 ITYAFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVLLSLTVFLLLITEIIP 459

  Fly   323 ATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFLYWLPCILRMQRP- 386
            :||..:||:|.|....|..|..|:|.|:.:||.|||:|.||.|..|:|.:||..:|.:|.|:||
  Rat   460 STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRVFLDIVPRLLFMKRPS 524

  Fly   387 ---------------------------GQVGY--------------------------------- 391
                                       |:.|.
  Rat   525 VVKDNCRRLIESMHKMANAPRFWPEPVGEPGILSDICNQGLSPAPTFCNPTDTAVETQPTCRSPP 589

  Fly   392 ---------------------ECPPPPSSSSSSASGEKKQ-QIQNVELKERSSKSLLANVLDIDD 434
                                 .||||.|||.:....:.:. .:|:|...:.::          :|
  Rat   590 LEVPDLKTSEVEKASPCPSPGSCPPPKSSSGAPMLIKARSLSVQHVPSSQEAA----------ED 644

  Fly   435 DFRCNHR----C-----ASATLPHQPTYYRTMYRQ-------GDDGS--------VGPVGPAGPV 475
            ..||..|    |     |::....:||...|..:.       .|..|        ..||.|...:
  Rat   645 GIRCRSRSIQYCVSQDGAASLADSKPTSSPTSLKARPSQLPVSDQASPCKCTCKEPSPVSPVTVL 709

  Fly   476 VDGRLHEAISHTCLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFT 540
            ..|.......|..|:.:    |...::.:::|.:.||.||....:..|||:.|||:||:.|.:|.
  Rat   710 KAGGTKAPPQHLPLSPA----LTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFI 770

  Fly   541 LFTIIATLAVLFSAP 555
            :..::.|:. ||..|
  Rat   771 IVCLLGTVG-LFLPP 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	196/602 (33%)
		Neur_chan_LBD	61..268	CDD:280998	95/206 (46%)
		Neur_chan_memb	275..552	CDD:280999	98/383 (26%)
Chrna4	XP_038960311.1	LGIC_ECD	199..405	CDD:355788	95/206 (46%)
		Cys-loop	323..337	CDD:349787	9/13 (69%)
		Neur_chan_memb	412..781	CDD:397193	98/383 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910