Protein Alignment nAChRalpha7 and Chrnb4

DIOPT Version :10

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_434693.1
• Gene: Chrnb4 / 25103
• RGDID: 2351
• Length: 495
• Species: Rattus norvegicus
• Alignment Length: 539
• Identity: 202/539 - (37%)
• Similarity: 301/539 - (55%)
• Gaps: 74/539 - (13%)

  Fly    38 GGRMLVYGLGLLIMIPACAAGPHEKRLLHALLD--NYNSLERPVVNESDPLQLSFGLTLMQIIDV 100
            |..:|:..|..|:....|.....|::|:..||:  .||:|.||..:.|..:.:...|:|.|:|.|
  Rat     3 GTPLLLVSLFSLLQDGDCRLANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIRLELSLSQLISV 67

  Fly   101 DEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNV 165
            :|:.|::.|:||||.||.|..|.||||.:.||..||||..|:|.||:::||:||..::.:..|||
  Rat    68 NEREQIMTTSIWLKQEWTDYRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNADGTYEVSVYTNV 132

  Fly   166 VVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFIT 230
            :||:|||..::||.|:||.|||::..||||.|.|.:||.|||||..::|:.|:... ..:..|..
  Rat   133 IVRSNGSIQWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKSPT-AIMDDFTP 196

  Fly   231 NGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPD 295
            :||||::.:||:|.   .|.....|:|:|:..:|:||.|:|..|||:|||||.|:|:|.|.||.|
  Rat   197 SGEWDIVALPGRRT---VNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSD 258

  Fly   296 SGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNP 360
            .|||::|.:::||:||.||.::::.:|.||..:||:|.|....|.:|..|:|:|:.:||.|||:|
  Rat   259 CGEKMTLCISVLLALTFFLLLISKIVPPTSLDIPLIGKYLLFTMVLVTFSIVTTVCVLNVHHRSP 323

  Fly   361 DTHEMSEWIRVIFLYWLPCILRMQRPG-QVGYECPPPPS----SSSSSASGEKKQQIQNVELKER 420
            .||.|:.|::..||:.||..|.|:||| :|.....|.||    :::.:|:
  Rat   324 STHTMASWVKECFLHKLPTFLFMKRPGLEVSLVRVPHPSQLHLATADTAA--------------- 373

  Fly   421 SSKSLLANVLDIDDDFRCNHRCASATLPHQPT--YYRTMYRQGDDGSVGPVGPAGPVVDGRLHEA 483
                                  .||..|..|:  |..:||      .|.|| ||.|      ..|
  Rat   374 ----------------------TSALGPTSPSNLYGSSMY------FVNPV-PAAP------KSA 403

  Fly   484 I-SHTC-------LTSSAEY--ELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLII 538
            : |||.       |.||..:  :|...|:.:.:|.:.|:.:|....:..||||.|||||||.|.:
  Rat   404 VSSHTAGLPRDARLRSSGRFREDLQEALEGVSFIAQHLESDDRDQSVIEDWKFVAMVVDRLFLWV 468

  Fly   539 FTLFTIIATLAVLFSAPHF 557
            |....|:.|:. ||..|.|
  Rat   469 FVFVCILGTMG-LFLPPLF 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	192/507 (38%)
Chrnb4	NP_434693.1	LIC	21..483	CDD:455710	195/516 (38%)
		LGIC_ECD	53..230	CDD:475126	78/180 (43%)