Protein Alignment nAChRalpha7 and Chrna5

DIOPT Version :10

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_058774.2
• Gene: Chrna5 / 25102
• RGDID: 2347
• Length: 467
• Species: Rattus norvegicus
• Alignment Length: 533
• Identity: 183/533 - (34%)
• Similarity: 277/533 - (51%)
• Gaps: 105/533 - (19%)

  Fly    32 PEATANGGRMLVYGLGLLIMIPACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQ 96
            |...|.|.|   .||..|     .:|..||..|...|.::|....|||.:.||.:::.|||.:.|
  Rat    26 PTGAARGTR---GGLPEL-----SSAAKHEDSLFRDLFEDYERWVRPVEHLSDKIKIKFGLAISQ 82

  Fly    97 IIDVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTY 161
            ::||||||||:.||:|||.||.|:.||||..::||::.:|:|...||.||::::::||..|:|.
  Rat    83 LVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKIIRVPSDSLWIPDIVLFDNADGRFEGA- 146

  Fly   162 ATNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDIS 226
            :|..|||.||:..:..|..:||:|.||:|:||||.|.|.||||||||||.|:|:.|:|: ..|.:
  Rat   147 STKTVVRYNGTVTWTQPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQ-DVDRT 210

  Fly   227 SFITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFT 291
            .|..||||:::...|.:.....:||..||  ||::.:|:|..|:|...||:||:.::.:.::.|.
  Rat   211 DFFDNGEWEIMSAMGSKGNRTDSCCWYPY--ITYSFVIKRLPLFYTLFLIIPCIGLSFLTVVVFY 273

  Fly   292 LPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYH 356
            ||.:.|||:||..::|:||||||.::.|.:|::|..:||:|.|....|..|..|::.|:..:|.|
  Rat   274 LPSNEGEKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIH 338

  Fly   357 HRNPDTHE-MSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKER 420
            ||:..||. |:.|:|.|||:.||.:|.|:
  Rat   339 HRSSSTHNAMAPWVRKIFLHKLPKLLCMR------------------------------------ 367

  Fly   421 SSKSLLANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGRLHEAIS 485
                                       .|...|: |...:.:.|       |||.....|..|:.
  Rat   368 ---------------------------SHADRYF-TQREEAESG-------AGPKSRNTLEAALD 397

  Fly   486 HTCLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLA- 549
              |               :|:||..:.||::..::..||||.|.|:||:.|..|.|.:||.||.
  Rat   398 --C---------------IRYITRHVVKENDVREVVEDWKFIAQVLDRMFLWTFLLVSIIGTLGL 445

  Fly   550 ---VLFSAPHFIV 559
               |::...:.||
  Rat   446 FVPVIYKWANIIV 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	170/489 (35%)
Chrna5	NP_058774.2	LGIC_ECD	45..251	CDD:475126	94/209 (45%)
		Neur_chan_memb	257..446	CDD:460753	76/276 (28%)