Protein Alignment nAChRalpha7 and pbo-6

DIOPT Version :10

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001294833.1
• Gene: pbo-6 / 24104421
• WormBaseID: WBGene00017375
• Length: 422
• Species: Caenorhabditis elegans
• Alignment Length: 346
• Identity: 101/346 - (29%)
• Similarity: 170/346 - (49%)
• Gaps: 26/346 - (7%)

  Fly    46 LGLLIMIPACAAGPHE---------KRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVD 101
            |.:.|.|.....|..|         .||...||:.:|....|    ...:.:|..:.|:.||.::
 Worm     6 LTIFIFITTVTVGVAEFSEQYQGSSSRLTRHLLEKHNKCSPP----DGRVDISHNIELVHIIGIN 66

  Fly   102 EKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSAD-EGFDGTYATNV 165
            |.||.:...:::..:|.|.:|.|...||.|::...:|.|.:|.||::::|:.: :.......:.:
 Worm    67 ELNQNMQVLVYIVQQWTDASLSWKVEEFRGIKHTWLPEHSIWIPDIIVFNTLEHKMLLEAVRSPI 131

  Fly   166 VVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFIT 230
            .|...|...|..|.|:...|:|.|..||||||.|:::|.||.||..::.|....:.  .:.::..
 Worm   132 KVSYTGEVTYAYPAIYTVLCQIGIATFPFDDQVCKIRFASWAYDEDKILLNASHKP--LLKNYSP 194

  Fly   231 NGEWDLLGVPGKRNEIYYNCCPEPYI-DITFAILIRRKTLYYFFNLIVPCVLIASMALLG----F 290
            |.||.|..|...|.|..:.   |..: :|.:.|.:.||..||..:|:||..:|..:::.|    |
 Worm   195 NEEWALQDVDMARKEYEHE---ETVVSEIIYYIKVARKPFYYLISLVVPSYIICVLSIAGLFARF 256

  Fly   291 TLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNY 355
            :...:..|:.:||||.:||:.|...:|.|.:|.:|:.||||..|.:.|:.||..:.:.|..::..
 Worm   257 STKHERQERFTLGVTAILSMAVLSLVVTEKVPHSSENVPLLIVYMHFIIVMVTIATILTSTVMRV 321

  Fly   356 HHRNPDTHEMS--EWIRVIFL 374
            |.:...||.:|  .|||.:.|
 Worm   322 HAKGFRTHFLSPPNWIRKVLL 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	97/333 (29%)
pbo-6	NP_001294833.1	Neur_chan_LBD	31..230	CDD:460752	58/207 (28%)
		LGIC_TM_cation	231..>322	CDD:349853	29/90 (32%)
		TM1 helix	231..259	CDD:349853	8/27 (30%)
		TM2 helix	267..288	CDD:349853	9/20 (45%)
		TM3 helix	299..321	CDD:349853	5/21 (24%)