Protein Alignment nAChRalpha7 and pbo-6

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001294833.1
• Gene: pbo-6 / 24104421
• WormBaseID: WBGene00017375
• Length: 422
• Species: Caenorhabditis elegans
• Alignment Length: 346
• Identity: 101/346 - (29%)
• Similarity: 170/346 - (49%)
• Gaps: 26/346 - (7%)

  Fly    46 LGLLIMIPACAAGPHE---------KRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVD 101
            |.:.|.|.....|..|         .||...||:.:|....|    ...:.:|..:.|:.||.::
 Worm     6 LTIFIFITTVTVGVAEFSEQYQGSSSRLTRHLLEKHNKCSPP----DGRVDISHNIELVHIIGIN 66

  Fly   102 EKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSAD-EGFDGTYATNV 165
            |.||.:...:::..:|.|.:|.|...||.|::...:|.|.:|.||::::|:.: :.......:.:
 Worm    67 ELNQNMQVLVYIVQQWTDASLSWKVEEFRGIKHTWLPEHSIWIPDIIVFNTLEHKMLLEAVRSPI 131

  Fly   166 VVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFIT 230
            .|...|...|..|.|:...|:|.|..||||||.|:::|.||.||..::.|....:.  .:.::..
 Worm   132 KVSYTGEVTYAYPAIYTVLCQIGIATFPFDDQVCKIRFASWAYDEDKILLNASHKP--LLKNYSP 194

  Fly   231 NGEWDLLGVPGKRNEIYYNCCPEPYI-DITFAILIRRKTLYYFFNLIVPCVLIASMALLG----F 290
            |.||.|..|...|.|..:.   |..: :|.:.|.:.||..||..:|:||..:|..:::.|    |
 Worm   195 NEEWALQDVDMARKEYEHE---ETVVSEIIYYIKVARKPFYYLISLVVPSYIICVLSIAGLFARF 256

  Fly   291 TLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNY 355
            :...:..|:.:||||.:||:.|...:|.|.:|.:|:.||||..|.:.|:.||..:.:.|..::..
 Worm   257 STKHERQERFTLGVTAILSMAVLSLVVTEKVPHSSENVPLLIVYMHFIIVMVTIATILTSTVMRV 321

  Fly   356 HHRNPDTHEMS--EWIRVIFL 374
            |.:...||.:|  .|||.:.|
 Worm   322 HAKGFRTHFLSPPNWIRKVLL 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	97/333 (29%)
		Neur_chan_LBD	61..268	CDD:280998	59/217 (27%)
		Neur_chan_memb	275..552	CDD:280999	35/106 (33%)
pbo-6	NP_001294833.1	Neur_chan_LBD	31..230	CDD:280998	58/207 (28%)
		Neur_chan_memb	264..>342	CDD:280999	28/77 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010