Protein Alignment nAChRalpha7 and acr-19

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001129756.1
• Gene: acr-19 / 191605
• WormBaseID: WBGene00000058
• Length: 560
• Species: Caenorhabditis elegans
• Alignment Length: 581
• Identity: 228/581 - (39%)
• Similarity: 335/581 - (57%)
• Gaps: 91/581 - (15%)

  Fly    42 LVYGLGLLIMIPACA----AGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDE 102
            ||..:.:||....|:    .|.||:||...|.:|||.|.|||.|||:.:.:..|:...||:|:||
 Worm     8 LVLSVSILIWETKCSKVIWTGDHERRLYAKLAENYNKLARPVRNESEAVVVLLGMDYQQILDIDE 72

  Fly   103 KNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVV 167
            |:|::.:|:||::.|.|..|.|:.||||.::::|:|.:.:||||||:|||.|:.||.|:..|.||
 Worm    73 KHQIMNSNVWLRMSWTDHYLTWDPSEFGNIKEVRLPINNIWKPDVLLYNSVDQQFDSTWPVNAVV 137

  Fly   168 RNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFIT-- 230
            ...|:..::||.|.:|:|.|||.:||||.|.|.||||||||.||..||         |::.|:
 Worm   138 LYTGNVTWIPPAIIRSSCAIDIAYFPFDTQHCTMKFGSWTYSGFFTDL---------INTTISPA 193

  Fly   231 ----NGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFT 291
                ||||:|||:..:|:..:|.||||||.|:||.:.|||:||||.|||::||:||:|:|||.||
 Worm   194 TYKPNGEWELLGLTSQRSIFFYECCPEPYYDVTFTVSIRRRTLYYGFNLLLPCMLISSLALLSFT 258

  Fly   292 LPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYH 356
            ||.|.||||:|||||.:||.||:.||||.||.||||:||:..||:||||.|.:|||:|::.||:|
 Worm   259 LPADCGEKLNLGVTIFMSLCVFMIMVAEAMPQTSDALPLIQIYFSCIMFQVGASVVATVIALNFH 323

  Fly   357 HRNPDTHE-MSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKER 420
            ||:|:.:: |:::::.:.|.|||.:|.|:||..:....     ..:..||..||:|.|.:...||
 Worm   324 HRSPEQYKPMNKFLKTLLLGWLPTLLGMERPDVLELSV-----HGAHYASDNKKKQRQYLIEVER 383

  Fly   421 --------SSKSLLANVLDIDDDFRCNHRCASATLPH------QPTYYRTMYRQGDDGSVGPVGP 471
                    :..|.:...:.:|         .|...||      .|:..||     ....:|..|.
 Worm   384 HILTRPNGNGHSAVDKAVHLD---------LSTGNPHSDAKKSSPSPKRT-----SASIMGMTGL 434

  Fly   472 AGPVVDGRLHEAIS-HTC------------------------LTSSAEYELA------------- 498
            ....::|.|..:|: :||                        :.::..|:.|
 Worm   435 PTTQMNGALDSSINKYTCTKVTRPLENGSATINHKSSPQINPINNNNIYKCANNQKTQFEDRHFH 499

  Fly   499 LILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLFSAPHFIV 559
            .||.|||.|:.:::||:....:..||.||:.||||:|.:.|:.|..:.|..:.::|||..|
 Worm   500 HILNELRVISARVRKEEAMHALQADWMFASRVVDRVCFLAFSAFLFMCTAIISYNAPHLFV 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	217/547 (40%)
		Neur_chan_LBD	61..268	CDD:280998	101/212 (48%)
		Neur_chan_memb	275..552	CDD:280999	110/329 (33%)
acr-19	NP_001129756.1	LIC	31..548	CDD:273305	216/544 (40%)
		Neur_chan_LBD	31..235	CDD:280998	101/212 (48%)
		Neur_chan_memb	242..>354	CDD:280999	63/111 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3025
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.050