Protein Alignment nAChRalpha7 and acr-17

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001023961.1
• Gene: acr-17 / 191603
• WormBaseID: WBGene00000056
• Length: 515
• Species: Caenorhabditis elegans
• Alignment Length: 549
• Identity: 151/549 - (27%)
• Similarity: 257/549 - (46%)
• Gaps: 67/549 - (12%)

  Fly    41 MLVYGLGLLIMIPACAAG---PHEKRLLHALLDNYNSLERPVVNESD-PLQLSFGLTLMQIIDVD 101
            |:.:.|.|.|::.....|   ..:|:|:..|..:|:...|||.:||. |..::..|...||..|.
 Worm     1 MISFQLLLRIVVLHFLMGLAMAQQKQLIKYLFRDYHKELRPVKDESSGPTNVTVQLYFKQIQKVH 65

  Fly   102 EKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGF-DGTYATNV 165
            |.:|::....|::..|.|..|.||.|:||.::.|.:|...:||||:|:||:|:... :....|||
 Worm    66 ENDQIITLYCWIEEYWQDEFLTWNPSDFGNIKSLHVPSEMIWKPDLLVYNNANMNIKENEMQTNV 130

  Fly   166 VVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQD---EAGGDISS 227
            .:.:.|........|...||.:.:..||:|.|.|.:...||:|||.|:.|...:   ||..||.:
 Worm   131 QIEHTGKISLFRAIITDITCDLQMEKFPYDQQICFIMLASWSYDGSQIMLNTAEQPTEAPLDIKN 195

  Fly   228 ---------FITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIA 283
                     :|.|.||.|:....:.|..||:|||.||.||::...|:|...||.|.||:|...|.
 Worm   196 TTNLAILNHYIPNMEWKLVDFRYRNNLKYYDCCPNPYPDISYFFAIKRNPSYYLFTLIIPSAFIT 260

  Fly   284 SMALLGFTLPPDS----GEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVAS 344
            .:.::||..|..|    .||:|||||.||||.:.|.||::.:||||::|||||.|:..::|::..
 Worm   261 IVTVIGFFTPHSSTGENTEKVSLGVTALLSLAIILMMVSDKLPATSNSVPLLGQYYIGLIFIMFL 325

  Fly   345 SVVSTILILNYHHRNPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSSSSSSASGEKK 409
            :...|...|....:......::..:|...|     .:||.|...|.:.......::..|.....|
 Worm   326 ATYCTTFTLGIQMQGNAGRPITRRLRSFLL-----SIRMNRNSFVQWFFGRELMNTQESIKMRLK 385

  Fly   410 QQIQNVELKERSSKSLL---ANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGP 471
            :..:..|||::.:...:   ..:|..|                :|.:.:|
 Worm   386 KYDKLSELKKKFANGFVQFQQKLLKTD----------------EPKHNKT--------------- 419

  Fly   472 AGPVVDGRLHEAISHTCLTSSAEYELAL-ILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLC 535
             ..:::   .|:|..:.|...|.|.:.: :|..::.|.:.|..::....|.::|:..|.:::::.
 Worm   420 -ASLIE---QESIDSSKLLDPAMYNVVVDVLSSVQSIRQDLTSQEHLKRIRKEWQMLARMLEKII 480

  Fly   536 LIIFTLFTIIATLAVLFSA--PHFIVSGV 562
            :.||.:.|:.....:|:..  |..|.:.|
 Worm   481 MWIFIISTVAFASFMLYDTQDPPIITNEV 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	142/510 (28%)
		Neur_chan_LBD	61..268	CDD:280998	75/220 (34%)
		Neur_chan_memb	275..552	CDD:280999	64/284 (23%)
acr-17	NP_001023961.1	LIC	23..491	CDD:273305	142/507 (28%)
		Neur_chan_LBD	24..245	CDD:280998	75/220 (34%)
		Neur_chan_memb	252..491	CDD:280999	64/278 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010