Protein Alignment nAChRalpha7 and acr-11

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_491906.1
• Gene: acr-11 / 191599
• WormBaseID: WBGene00000050
• Length: 461
• Species: Caenorhabditis elegans
• Alignment Length: 530
• Identity: 217/530 - (40%)
• Similarity: 308/530 - (58%)
• Gaps: 87/530 - (16%)

  Fly    42 LVYGLGLLIMIPA--CAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKN 104
            |:..:..|::|.:  |.....|.:|...||..||.|||||.|.|.||::...|.|.||:||||||
 Worm     5 LINSILSLVIIHSNLCDGSVAETKLFTDLLKGYNPLERPVQNSSQPLEVKIKLFLQQILDVDEKN 69

  Fly   105 QLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIP--PHRLWKPDVLMYNSADEGFDGTYATNVVV 167
            |::..|.||...|.|..|:|...::||::|:|.|  ...:||||||:||||.|.||.|:.:|::.
 Worm    70 QIVSVNAWLSYTWFDHKLQWEPKKYGGIQDIRFPGSSDHIWKPDVLLYNSAAEDFDSTFKSNLLT 134

  Fly   168 RNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGG----DISSF 228
            .:.|:.:::|||:.|..|::|:||||||||.|||||||||:.|:.:|||:.|:..|    |:|::
 Worm   135 YHTGTVVWIPPGVLKFVCQLDVTWFPFDDQVCEMKFGSWTFHGYAIDLQIDDDTNGTQSMDLSTY 199

  Fly   229 ITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLP 293
            :.||||.::....||...||.||||||..:.:.:.|||:||||.||||:|.:||:.||:|||..|
 Worm   200 LVNGEWQVISTNAKRVVSYYKCCPEPYPTVNYYLHIRRRTLYYGFNLIIPSLLISLMAILGFMFP 264

  Fly   294 PDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHR 358
            ||:|||::|.|||||::..||:||:|..|.||:||||:|.:|:|.|.:|::|||.||::||.|.|
 Worm   265 PDAGEKITLEVTILLAIVFFLSMVSEMTPPTSEAVPLIGVFFSCCMLVVSASVVFTIVVLNLHFR 329

  Fly   359 NPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKERSSK 423
            :.|:|||:..:|.:.|.:||.:|.|.|||.                                  |
 Worm   330 SADSHEMNPLVRRVLLEFLPWLLFMSRPGY----------------------------------K 360

  Fly   424 SLLANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGRLHEAISHTC 488
            .:.|||:|..|..                               |..|..| :|..|.
 Worm   361 FVKANVIDSTDKM-------------------------------PKKPKNP-LDCNLP------- 386

  Fly   489 LTSSAEYELALIL-----KELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATL 548
             ::.|.||..::|     .|||.:.....||:....|..||:||||||||.||::||:|.:|:.|
 Worm   387 -SNHAGYEAQILLLHSVHTELRRVVAFYNKEEHDERIQTDWRFAAMVVDRACLLLFTVFIVISIL 450

  Fly   549 AVLFSAPHFI 558
            |::.||||.|
 Worm   451 AIMMSAPHII 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	206/499 (41%)
		Neur_chan_LBD	61..268	CDD:280998	102/212 (48%)
		Neur_chan_memb	275..552	CDD:280999	100/281 (36%)
acr-11	NP_491906.1	LIC	25..456	CDD:273305	208/504 (41%)
		Neur_chan_LBD	26..239	CDD:280998	102/212 (48%)
		Neur_chan_memb	246..447	CDD:280999	97/274 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3299
OMA	1	1.010	-	-		QHG45242
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	1	1.000	-	-		mtm4815
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3025
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.770