DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha7 and acr-10

DIOPT Version :9

Sequence 1:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_508692.3	Gene:	acr-10 / 191598	WormBaseID:	WBGene00000049	Length:	557	Species:	Caenorhabditis elegans

Alignment Length:	578	Identity:	192/578 - (33%)
Similarity:	292/578 - (50%)	Gaps:	94/578 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LVYGLGLLIMIPACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQL 106
            |.:.|.|:|:...|:..  |.:|...:|..|..|.|||....:.|::...:.|.||:::|.:||:
Worm    10 LFFILSLIIIESECSKA--ENKLYRDILQGYLKLARPVRYPRNVLKVHMKVFLQQILNLDGQNQI 72

  Fly   107 LITNIWLKLEWNDMNLRWNSSEFGGVRDLRIP--PHRLWKPDVLMYNSADEGFDGTYATNVVVRN 169
            :..|.|||..|.|..|:|:..::..:..:|..  .:::|:||:|:||||.|.||.::.:|.||.|
Worm    73 IEVNAWLKYVWMDYRLQWDPLQYDNITSIRFAGGENQIWRPDILLYNSASEDFDSSFKSNEVVYN 137

  Fly   170 NGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQL-----QDEAGGDISSFI 229
            .|...::|||||:::||:|||:||||||.|.:|||||||.|..|||.:     ..|...|:|::.
Worm   138 TGEVNWIPPGIFRASCKMDITYFPFDDQVCYLKFGSWTYHGLALDLSIIAEEDDSELSIDLSTYT 202

  Fly   230 TNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPP 294
            .:|||.|...|..::..|.:||.|||..:||.:.:||:||:|.||:|:|.:||:.|.|:||.||.
Worm   203 PSGEWHLTKAPAVKDVKYNSCCKEPYSTVTFYMFLRRRTLFYLFNIILPSLLISIMTLMGFCLPA 267

  Fly   295 -DSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHR 358
             |..||:....|||||:..|:.:|:|..|.||::|||||.:|:.:..:.:.|...||.:||:.:|
Worm   268 HDMSEKIGYQTTILLSICFFVTIVSEMTPPTSESVPLLGMFFSSLTLISSVSTAFTITVLNFRYR 332

  Fly   359 NPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYE----------------------CPPPP---- 397
            ......|......:||.|:|.:|.|:||| |.|:                      ||.||
Worm   333 QVQNIHMHPIFYKVFLIWIPWLLLMKRPG-VFYKKRRATVQAREEISFFDNGDDDCCPKPPEFDY 396

  Fly   398 SSSSSSASGEKKQQIQNVELKERSSKSLLANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGD 462
            |.|..||        ..:.|..| .|.||..:..:                  |..:..:.|:..
Worm   397 SLSIDSA--------DTLPLPPR-PKPLLKKMHSV------------------PAEHLHLDRKVG 434

  Fly   463 DGSVGPVGPAGPVV-------------------DGRLHEAISHTCLTSSAEYEL--ALILKELRW 506
            ||.:  .....|:|                   :..:.:.|....|..::.|..  .:|:...|.
Worm   435 DGIL--KSQRRPLVLTKNVNKSHSLRSRRFTQFEKYIKKCIDDAKLRKNSTYSTYSMMIITYYRQ 497

  Fly   507 ITEQLKKEDETSDITR-------DWKFAAMVVDRLCLIIFTLFTIIATLAVLFSAPHF 557
            |.|.||..:...|..|       |||||||.:|||||::.||..::....::.|.|||
Worm   498 IDEMLKLLNRRLDKQRKYLFKQEDWKFAAMALDRLCLLLITLLIVMCLFGMILSTPHF 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	183/550 (33%)
		Neur_chan_LBD	61..268	CDD:280998	86/213 (40%)
		Neur_chan_memb	275..552	CDD:280999	92/331 (28%)
acr-10	NP_508692.3	Neur_chan_LBD	27..241	CDD:280998	86/213 (40%)
acr-10	NP_508692.3	Neur_chan_memb	248..>361	CDD:280999	44/112 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880