Protein Alignment nAChRalpha7 and acr-6

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_491354.2
• Gene: acr-6 / 191479
• WormBaseID: WBGene00000045
• Length: 551
• Species: Caenorhabditis elegans
• Alignment Length: 548
• Identity: 179/548 - (32%)
• Similarity: 264/548 - (48%)
• Gaps: 57/548 - (10%)

  Fly    48 LLIMIPACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIW 112
            ||..|..|:...: |.|...||..||.:..|....::.|.:.|.|.|.||:||.||:|::.....
 Worm     8 LLFSIRLCSFTAY-KSLFETLLARYNKIAFPSGEFNNTLTIEFKLRLDQIVDVHEKDQVITLKGT 71

  Fly   113 LKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGSCLYVP 177
            |...|.|..|.||..|||.:..:..|...||.||:::||:|......:..|.|.|...|...:.|
 Worm    72 LIHHWLDYRLSWNPDEFGNITLMHFPGEMLWLPDIILYNNAHGSPWVSETTQVHVSFEGRVTWQP 136

  Fly   178 PGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDL------QLQD------------EAGGD 224
            |.::.:.|.|||.|:|:|.|.||:|||||||.|.||:|      |..:            |.|.|
 Worm   137 PVVYDAFCNIDIEWYPYDLQICELKFGSWTYGGSQLNLIHLTTDQANESTDATGDNVWKVERGVD 201

  Fly   225 ISSFITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLG 289
            :|::..:.|||||.|.|.|::.:|.||..|.||||:.:.||||.|:|..|:|:|||.:|||.|..
 Worm   202 LSNYQESVEWDLLSVEGIRHKKWYPCCDYPSIDITYYLHIRRKKLFYTVNMIIPCVCLASMTLWV 266

  Fly   290 FTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILN 354
            |.||.:|.:|:.|.:::|::||::..|:.:.:|.||...||:..|.:..|.|||.||..|:.|.|
 Worm   267 FYLPCESHQKIQLCISVLVALTLYFLMLIDIIPPTSIVTPLILKYLSFTMIMVALSVTCTVFIQN 331

  Fly   355 YHHR---NPDTHEMSEWIRVIFLYWLP---CILRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQ 413
            .|:|   .|....:..|    |:..|.   .|.|.....|...........::.||....::|.|
 Worm   332 IHYRAYYQPMPRFVKHW----FIEKLGKKLLISRKTEQAQYHRTAQHVKQVNALSAMNILEKQFQ 392

  Fly   414 ----NVELKERSSKSLLA---NVLDIDDDFRCNHRCASATL--PHQPTYYRTMYR-----QGDDG 464
                .:|:...:.|::.|   .|..|..:....:|..|..:  |........|.|     ..||
 Worm   393 KTLFELEIATMAKKTVTAAPKTVNSIFLELPMMNRSVSVKIRKPSVKAVKNRMRRLLSIDMTDD- 456

  Fly   465 SVGPVGPAGPVVDGRLHEAIS--HTCLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFA 527
                       :.|:..|.||  .|..|.....:|....|.:.:|.:.|..|....:...||:|.
 Worm   457 -----------IRGKETEEISPETTKDTDPDREKLRKAEKNIHFIAKTLTDERRAQEAEADWQFV 510

  Fly   528 AMVVDRLCLIIFTLFTIIATLAVLFSAP 555
            ::|:||:.||||:....|.|:..:||||
 Worm   511 SLVIDRMLLIIFSFTITIGTILTIFSAP 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	170/528 (32%)
		Neur_chan_LBD	61..268	CDD:280998	86/224 (38%)
		Neur_chan_memb	275..552	CDD:280999	81/298 (27%)
acr-6	NP_491354.2	Neur_chan_LBD	23..244	CDD:280998	84/220 (38%)
		Neur_chan_memb	252..524	CDD:280999	79/287 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910