DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha7 and lgc-19

DIOPT Version :9

Sequence 1:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_502905.2	Gene:	lgc-19 / 190895	WormBaseID:	WBGene00013655	Length:	400	Species:	Caenorhabditis elegans

Alignment Length:	335	Identity:	77/335 - (22%)
Similarity:	151/335 - (45%)	Gaps:	52/335 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 LDNYNSLERPVVNESDP----------LQLSFG--------------LTLMQIIDVDEKNQLLIT 109
            ||...:|.:.:..:.||          :.|..|              |..:::::|.|..:.:..
Worm    31 LDVQRNLTKHIFRDYDPTVSPVYTWVDVDLPIGYDNEAPKRYNYTIFLYYLKLVEVQEPQEKISV 95

  Fly   110 NIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSAD-EGFDGTYATNVVVRNNGSC 173
            .:.:...|.|..|.||:|.:.....:.:...::|.|.:.::...| ..|.......:.:.|.|..
Worm    96 VMEIMEYWYDARLSWNASAWQNTTMIYMKQDKVWSPTISVFGVNDIVDFRDNDNRLICIENTGFI 160

  Fly   174 L-YVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDL------QLQDEAGGDISSFITN 231
            . ||...: .:.|::|::.||||.|.|:::|....:...|:|:      ::.||.   |...:.|
Worm   161 WDYVSVRV-SANCEMDVSRFPFDTQICQIRFCLPIFYRVQVDILNEIYEEIMDER---IFKTMGN 221

  Fly   232 GEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLG-FTLPPD 295
            .||.||.:..:...:.||..........|.|.|||..|||.:.::.|..:|..::::| |....|
Worm   222 SEWKLLNLTNRVEALVYNDNMGTMDLAIFEITIRRNPLYYIYMIVFPSFIINFVSIVGVFLNGAD 286

  Fly   296 SGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTY--FNCIMFMVASSVVSTILILNYHHR 358
            ...:|::|:|.::::|..|.::|:.:|.|.: :||||.|  .|.::.::|.::|:.|.
Worm   287 KMSRLNVGLTNIMTMTFILGVMADKIPRTGN-IPLLGIYIIINLVIMLIAIAIVTAIT------- 343

  Fly   359 NPDTHEMSEW 368
                 |:.:|
Worm   344 -----ELRKW 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	77/335 (23%)
		Neur_chan_LBD	61..268	CDD:280998	50/230 (22%)
		Neur_chan_memb	275..552	CDD:280999	24/97 (25%)
lgc-19	NP_502905.2	LGIC_ECD_cation	75..257	CDD:349790	42/185 (23%)
		LGIC_TM_cation	259..>346	CDD:349853	26/99 (26%)
		TM1 helix	263..284	CDD:349853	4/20 (20%)
		TM2 helix	292..313	CDD:349853	5/20 (25%)
		TM3 helix	323..346	CDD:349853	6/34 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010