Protein Alignment nAChRalpha7 and pbo-5

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001024240.1
• Gene: pbo-5 / 189903
• WormBaseID: WBGene00012857
• Length: 509
• Species: Caenorhabditis elegans
• Alignment Length: 420
• Identity: 108/420 - (25%)
• Similarity: 193/420 - (45%)
• Gaps: 57/420 - (13%)

  Fly    53 PACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEW 117
            ||...| ..|||...||..:| |..|   ....|.:.:.|.|:.|:.:||..|.:...|::...|
 Worm    60 PAFVPG-SSKRLTEYLLSRHN-LNAP---PDGLLYVEYELELVHILGIDELKQTMTVLIYVDEHW 119

  Fly   118 NDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNS------ADEGFDGTYATNVVVRNNGSCLYV 176
            .|.:|.|:.:.|||:....||..::|.||::::|.      |.|...........:..||:.:..
 Worm   120 VDPSLTWDPALFGGITKTWIPLDKIWVPDIIVFNMVKSNRLAHEDLLSAVRAPARIHYNGTIVAS 184

  Fly   177 PPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGEWDLLGVPG 241
            .|.:...:|:|:|..||.|||||.::..||.|.  |..::|.......:..:..|.||.||.:
 Worm   185 HPAVHTVSCEINIRHFPLDDQRCAIEIASWAYG--QEKIRLHAHTDHSLEHYKRNEEWHLLNL-- 245

  Fly   242 KRNEIYYNCCPEPY-------IDITFAILIRRKTLYYFFNLIVPCVLIASMALLG----FTLPPD 295
                   |...|.|       .::.|.|.::|:.|:|...|..|..::.:::::|    |:...:
 Worm   246 -------NVSEEKYEHEGVEVSEVKFEISLKRRPLFYMVTLTFPSYIMCAISVVGLFARFSTTGE 303

  Fly   296 SGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNP 360
            ..|:.:||||.:|::.|...:|:|.:|.:|..||||..||...|.:|:.:.::|.:::..|....
 Worm   304 REERFTLGVTAILTMAVLSLVVSEKVPHSSTHVPLLVAYFLFNMVIVSIAAMTTGIVMKVHRLGR 368

  Fly   361 DTHEMSEWIRVIFLYWLPCIL-------RMQRPGQVGYECPPPPSSSSSSASGE----KKQQIQN 414
            ...|.|:       :|:.|.|       ..:|..::..|.|......|.:.:||    |..::..
 Worm   369 YGDEPSD-------FWMRCFLLKPVFRTSNRRKYRMNPEEPTQVILVSEAKNGEVLTKKSTELNG 426

  Fly   415 VELKERSSKSLLANVLDIDDDF--RCNHRC 442
            ..:||    .:|::.|:..:::  :..:||
 Worm   427 TVVKE----IMLSSRLEALEEYIRKMVNRC 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	105/414 (25%)
		Neur_chan_LBD	61..268	CDD:280998	60/219 (27%)
		Neur_chan_memb	275..552	CDD:280999	43/185 (23%)
pbo-5	NP_001024240.1	Neur_chan_LBD	68..272	CDD:280998	60/218 (28%)
		Neur_chan_memb	306..>364	CDD:280999	20/57 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010