Protein Alignment nAChRalpha7 and lgc-18

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_510029.3
• Gene: lgc-18 / 187977
• WormBaseID: WBGene00011360
• Length: 399
• Species: Caenorhabditis elegans
• Alignment Length: 326
• Identity: 79/326 - (24%)
• Similarity: 152/326 - (46%)
• Gaps: 49/326 - (15%)

  Fly    60 HEKRLLHALLDNYNSLERPVVNESDPLQ----------------LSFGLTLMQIIDVDEKNQLLI 108
            ::.:|:..:..||::...||..:.||.|                ..:.|.|:::|:.:||..:::
 Worm    33 NQVKLIKDVFTNYDNTLSPVYTKIDPTQPIGYNPLAPKRFNYTVSLYYLKLVEVIEPEEKVSVVL 97

  Fly   109 TNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSAD-EGFDGTYATNVVVRNNGS 172
            .   :...|.|..:.|:||.:|.::.|.:...::|.|.:.::...| ..|.......|.|.|.|.
 Worm    98 E---MAEYWYDPRIAWDSSLYGDIKMLHMRQDKVWSPTLSLFRINDIADFRDPDFRMVCVENTGH 159

  Fly   173 CLYVPPGIFKSTCKIDITWFPFDDQRCEMKFG------------SWTYDGFQLDLQLQDEAGGDI 225
            ............|.:|::.||:|.|.|.::|.            |..|:|. |:..:.::.|
 Worm   160 TYTTLSVKISLNCPLDVSMFPYDSQTCRIQFNMPLFFMQQVEMFSQIYEGI-LNSTVWEKMG--- 220

  Fly   226 SSFITNGEWDLLGVPGKRNEIYYNCCPEPYIDI---TFAILIRRKTLYYFFNLIVPCVLIASMAL 287
                 |.||:|..:......:.|.   :...|:   ||.|.|||..:||.:.:|.|..:|.::::
 Worm   221 -----NSEWELANLTHSVELLSYG---DGLGDMQLATFEIRIRRNPMYYIYMIIFPSFIINALSI 277

  Fly   288 LG-FTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTIL 351
            :| |....|...||::|:|.::::|..|.::|:.:|.|. ::||||.|....:|::..:|..||:
 Worm   278 IGVFLKKTDKMSKLNVGLTNIMTMTFILGVMADKIPKTG-SIPLLGIYIIVNLFIMIVAVGLTIV 341

  Fly   352 I 352
            :
 Worm   342 L 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	79/326 (24%)
		Neur_chan_LBD	61..268	CDD:280998	53/238 (22%)
		Neur_chan_memb	275..552	CDD:280999	24/79 (30%)
lgc-18	NP_510029.3	LGIC_ECD_cation	75..257	CDD:349790	44/196 (22%)
		LGIC_TM_cation	259..>341	CDD:349853	25/82 (30%)
		TM1 helix	263..284	CDD:349853	5/20 (25%)
		TM2 helix	292..313	CDD:349853	5/20 (25%)
		TM3 helix	323..341	CDD:349853	4/17 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010