Protein Alignment nAChRalpha7 and lgc-16

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_510027.2
• Gene: lgc-16 / 187975
• WormBaseID: WBGene00011358
• Length: 401
• Species: Caenorhabditis elegans
• Alignment Length: 355
• Identity: 80/355 - (22%)
• Similarity: 156/355 - (43%)
• Gaps: 87/355 - (24%)

  Fly    61 EKRLLHALLDNYNSLERPV---VNESDPL----------QLSFGLTLMQIIDVDEKNQLLITNIW 112
            ::.|.:.|..||:.....|   :.:.:||          ..:..|..:::::|.|..:.:...:.
 Worm    36 QENLTNDLFANYDPTISTVYADIADWEPLGDNPRTIDRWNYTILLYYLKLVEVQEPAEKVSVVLE 100

  Fly   113 LKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKP--------DVLMYNSAD--------EGFDGTY 161
            |...|.|..|.||.|.:..|..:.....::|.|        :::.:...|        .|:...|
 Worm   101 LVERWYDPRLSWNISLYSNVSTIFARQEKVWSPTLSPFGVNEIIDFRDQDFRLISIDFTGYLNDY 165

  Fly   162 ATNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFG------------SWTYDGFQLD 214
            .:..|..|               |.:|::.||||.|.|:::|.            :..|:|.
 Worm   166 LSVRVSAN---------------CPMDVSRFPFDSQTCQIRFCLPIFNIRQVKILNEIYEGI--- 212

  Fly   215 LQLQDEAGGDISSFITNGEWDLLGVPGKRNEIYYNCCPEPY--IDI-TFAILIRRKTLYYFFNLI 276
              ||::    |...:.|.||.::.:..:..::.|:   :.|  :|: .|.|.|||..|||.:.::
 Worm   213 --LQEK----IIKTMGNSEWKVVSLTNRVEQLKYD---DDYGNMDLAVFEITIRRNPLYYIYMIV 268

  Fly   277 VPCVLIASMALLG-FTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTY--FNCI 338
            .|..:|..::::| |....|...||::|:|.::::|..|.::|:.:|.|. ::||||.|  .|.:
 Worm   269 FPSFVINGISIVGIFLKSADKMSKLNVGLTNIMTMTFILGVMADKIPRTG-SIPLLGIYIIINLL 332

  Fly   339 MFMVASSVVSTILILNYHHRNPDTHEMSEW 368
            :.::|.:||  :||.          |:.:|
 Worm   333 IMIIAITVV--VLIT----------ELRQW 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	80/355 (23%)
		Neur_chan_LBD	61..268	CDD:280998	50/250 (20%)
		Neur_chan_memb	275..552	CDD:280999	27/97 (28%)
lgc-16	NP_510027.2	LGIC_ECD_cation	77..259	CDD:349790	42/208 (20%)
		LGIC_TM	261..>317	CDD:365787	16/55 (29%)
		TM1 helix	261..284	CDD:349850	6/22 (27%)
		TM2 helix	291..315	CDD:349850	7/23 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010