Protein Alignment nAChRalpha7 and lgc-16

DIOPT Version :10

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_510027.2
• Gene: lgc-16 / 187975
• WormBaseID: WBGene00011358
• Length: 401
• Species: Caenorhabditis elegans
• Alignment Length: 355
• Identity: 80/355 - (22%)
• Similarity: 156/355 - (43%)
• Gaps: 87/355 - (24%)

  Fly    61 EKRLLHALLDNYNSLERPV---VNESDPL----------QLSFGLTLMQIIDVDEKNQLLITNIW 112
            ::.|.:.|..||:.....|   :.:.:||          ..:..|..:::::|.|..:.:...:.
 Worm    36 QENLTNDLFANYDPTISTVYADIADWEPLGDNPRTIDRWNYTILLYYLKLVEVQEPAEKVSVVLE 100

  Fly   113 LKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKP--------DVLMYNSAD--------EGFDGTY 161
            |...|.|..|.||.|.:..|..:.....::|.|        :::.:...|        .|:...|
 Worm   101 LVERWYDPRLSWNISLYSNVSTIFARQEKVWSPTLSPFGVNEIIDFRDQDFRLISIDFTGYLNDY 165

  Fly   162 ATNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFG------------SWTYDGFQLD 214
            .:..|..|               |.:|::.||||.|.|:::|.            :..|:|.
 Worm   166 LSVRVSAN---------------CPMDVSRFPFDSQTCQIRFCLPIFNIRQVKILNEIYEGI--- 212

  Fly   215 LQLQDEAGGDISSFITNGEWDLLGVPGKRNEIYYNCCPEPY--IDI-TFAILIRRKTLYYFFNLI 276
              ||::    |...:.|.||.::.:..:..::.|:   :.|  :|: .|.|.|||..|||.:.::
 Worm   213 --LQEK----IIKTMGNSEWKVVSLTNRVEQLKYD---DDYGNMDLAVFEITIRRNPLYYIYMIV 268

  Fly   277 VPCVLIASMALLG-FTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTY--FNCI 338
            .|..:|..::::| |....|...||::|:|.::::|..|.::|:.:|.|. ::||||.|  .|.:
 Worm   269 FPSFVINGISIVGIFLKSADKMSKLNVGLTNIMTMTFILGVMADKIPRTG-SIPLLGIYIIINLL 332

  Fly   339 MFMVASSVVSTILILNYHHRNPDTHEMSEW 368
            :.::|.:||  :||.          |:.:|
 Worm   333 IMIIAITVV--VLIT----------ELRQW 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	80/355 (23%)
lgc-16	NP_510027.2	LGIC_ECD_cation	77..259	CDD:349790	42/208 (20%)
		Cys-loop	174..188	CDD:349790	7/13 (54%)
		LGIC_TM	261..>317	CDD:476813	16/55 (29%)
		TM1 helix	265..284	CDD:349850	3/18 (17%)
		TM2 helix	291..315	CDD:349850	7/23 (30%)