Protein Alignment nAChRalpha7 and lgc-15

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_510025.2
• Gene: lgc-15 / 187973
• WormBaseID: WBGene00011356
• Length: 399
• Species: Caenorhabditis elegans
• Alignment Length: 332
• Identity: 77/332 - (23%)
• Similarity: 146/332 - (43%)
• Gaps: 65/332 - (19%)

  Fly    61 EKRLLHALLDNYNSLERPVVNESDPLQ----------------LSFGLTLMQIIDVDEKNQLLIT 109
            :..|...|...|::...||..:.||.|                |.|.|.|:::.:..||    ::
 Worm    35 QTNLTKNLFSGYDATISPVYTKVDPTQPLGHDPDAPGRWNYTLLLFSLKLVEVTEPQEK----VS 95

  Fly   110 NIWLKLE-WNDMNLRWNSSEFGGVRDLRIPPHRLWKP----------------DVLMYNSADEGF 157
            .:...:| |.|..|.||..::..:..:......:|.|                |..:......|.
 Worm    96 VVMEVMEYWFDARLTWNKEDYDDIASIYTRQANVWSPTLSAFGVSELVDLRDTDFRLVGITSYGM 160

  Fly   158 DGTYATNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAG 222
            ..||.:.:|..|               |.:|:..||||.|.|:::|....:..:::::..:..||
 Worm   161 VNTYVSVLVSAN---------------CPMDVYKFPFDYQTCQIRFCIPVFTSYEVEIFNEIYAG 210

  Fly   223 ---GDISSFITNGEWDLLGVPGKRNEIYYNCCPEPYIDI---TFAILIRRKTLYYFFNLIVPCVL 281
               .:....:.|.||:|:.:..:...:.|:   :.:.::   ||.|.|||..|||.:.:|.|..:
 Worm   211 VLTSNAWKTMGNSEWNLVNLTHRVETLKYD---DGFANLDLGTFEIKIRRNPLYYIYMIIFPSFI 272

  Fly   282 IASMALLG-FTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYF--NCIMFMVA 343
            |..::::| |....|...||::|:|.::::|..|.::|:.:|.|. .:||||.|.  |.::.::|
 Worm   273 INVVSIIGVFLKGADKMSKLNVGLTNIMTMTFILGVMADKIPRTG-TIPLLGVYIITNLVIMLIA 336

  Fly   344 SSVVSTI 350
            ..:|:.|
 Worm   337 IGIVTVI 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	77/332 (23%)
		Neur_chan_LBD	61..268	CDD:280998	50/245 (20%)
		Neur_chan_memb	275..552	CDD:280999	24/79 (30%)
lgc-15	NP_510025.2	LGIC_ECD_cation	74..258	CDD:349790	41/205 (20%)
		LGIC_TM_cation	260..>343	CDD:349853	26/83 (31%)
		TM1 helix	264..285	CDD:349853	5/20 (25%)
		TM2 helix	293..314	CDD:349853	5/20 (25%)
		TM3 helix	324..343	CDD:349853	4/18 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010