DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha7 and lgc-12

DIOPT Version :9

Sequence 1:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_498656.3	Gene:	lgc-12 / 187855	WormBaseID:	WBGene00020048	Length:	428	Species:	Caenorhabditis elegans

Alignment Length:	306	Identity:	92/306 - (30%)
Similarity:	154/306 - (50%)	Gaps:	11/306 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 HEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRW 124
            :|:.|:..|:.:|....|||.|.|..|.::....:..:::|:|:|:.:...||....|.|..|.|
Worm    28 NERELVKHLMKDYYQFTRPVKNYSSMLTVTIMPQIYNLVEVNEQNEQIKLLIWFPQSWKDDYLVW 92

  Fly   125 NSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGSCLYVPPGIFKSTCKIDI 189
            :..|:.|:..:.||...:|.||..::|:.:| .|.....||.|..||........:....|.:.:
Worm    93 DPDEWDGIEKITIPKSMVWLPDGYIFNTVEE-TDTLDNHNVRVHYNGKVEVDFNKLIDLICPMSV 156

  Fly   190 TWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGEWDLLGVPG-KRNEIYYNCC-- 251
            ..||||.|.|.::||||||....|...:.:   ..::....|.|||::.... |:...|.|..
Worm   157 LSFPFDVQLCALQFGSWTYQSHALSFNVLE---ASVNENNKNSEWDIVAFNATKKVSKYMNLIGG 218

  Fly   252 PEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLP----PDSGEKLSLGVTILLSLTV 312
            ...|.:|.:.:.:|||.|||...:::|..||.:::.:|...|    .|..|.:|||:|.:|::.|
Worm   219 DNVYEEIFYFLEVRRKPLYYIVVILIPTFLIVTVSNIGLFTPHGVHGDREEHVSLGLTTMLTMAV 283

  Fly   313 FLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHR 358
            .|:||...||.:|:.:||||.|......:...:|:.::||:..|.|
Worm   284 ILDMVTGQMPKSSEGIPLLGMYVLIEFALSIMAVLVSVLIIFAHER 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	92/306 (30%)
		Neur_chan_LBD	61..268	CDD:280998	59/209 (28%)
		Neur_chan_memb	275..552	CDD:280999	29/88 (33%)
lgc-12	NP_498656.3	Neur_chan_LBD	29..235	CDD:280998	59/209 (28%)
lgc-12	NP_498656.3	Neur_chan_memb	242..>345	CDD:280999	29/88 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845098at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020