Protein Alignment nAChRalpha7 and lgc-30

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_500015.3
• Gene: lgc-30 / 186551
• WormBaseID: WBGene00019069
• Length: 529
• Species: Caenorhabditis elegans
• Alignment Length: 532
• Identity: 121/532 - (22%)
• Similarity: 219/532 - (41%)
• Gaps: 91/532 - (17%)

  Fly    47 GLLIMIPACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNI 111
            |.:|..|.....||.:  |...:.::.....|:.:....:.:.....|.||:|:|::|.|...:.
 Worm    53 GQVIADPDADGDPHGR--LATWIRSHARHHIPLKHPHTRIDVFISAGLYQIVDLDQRNNLATVSA 115

  Fly   112 WLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYA--TNVVVRNNGSCL 174
            :|.:.|||..::|....|||:..:.:|...:|||:..||:|. .|....||  .:..:..||...
 Worm   116 YLDVHWNDDFIKWKPEIFGGIERIFVPIKWIWKPEFYMYHSV-YGRVPDYAPDASAELHYNGLVR 179

  Fly   175 YVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDL--QLQDEAGGDISSFITNGEW--- 234
            .......||.|.|:...||||.|.|....|||.|....::|  ..|:.|   :..|..|.||
 Worm   180 MFVSISSKSFCPINFKRFPFDSQTCSFSCGSWAYQSNIVNLVAAKQEIA---LEDFYDNQEWLLT 241

  Fly   235 DLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDS--- 296
            |.....|....:  :...|.:..:...:.::|::.||.|||:.|..|::.:|::||..|.::
 Worm   242 DARLFNGTTRNV--SAANESFSMVYMQLDLKRQSFYYVFNLVFPTTLVSLVAVIGFHAPINATGR 304

  Fly   297 -GEKLSLGVTILLSLTVFLNMVA-------ETMP----ATSDAVPLLGTYFNCIMFMVASSVVST 349
             ..|..||:..|||::|.|.|:.       |::|    :.|| |||:|.|:..::.:|:.:..::
 Worm   305 RESKFRLGIMTLLSMSVMLLMLVGEMKFAMESVPGQRGSFSD-VPLMGIYYMTLICIVSIATCTS 368

  Fly   350 ILILN---YHHRNPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSSSSSSASGEKKQQ 411
            .:.::   :..|||....:..:||.:....|.|             |..|.|......:..:...
 Worm   369 SIFVHLEKFALRNPSWQSVPWYIRWLAAKKLFC-------------CYVPKSFRYDKDAYSRNNN 420

  Fly   412 IQNVELKERSSKSLLANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVV 476
            :|.:.|.....:::..|::..:.:|                   |...|
 Worm   421 VQAISLHSTPDRNVAKNLIPKEINF-------------------TEVNQ---------------- 450

  Fly   477 DGRLHEAISHTCLTSSAE--YELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIF 539
            |..||:.:.    ..|||  .::.||:..||.|....::...:..:...|.   .::.|...:..
 Worm   451 DAPLHDVLE----GPSAEKTQKIDLIVSLLREIIHLKERIGASGQLAPYWD---QIISRCEKVSL 508

  Fly   540 TLFTIIATLAVL 551
            :.:..:.|:.||
 Worm   509 SFYLFLITINVL 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	115/515 (22%)
		Neur_chan_LBD	61..268	CDD:280998	54/213 (25%)
		Neur_chan_memb	275..552	CDD:280999	58/297 (20%)
lgc-30	NP_500015.3	Neur_chan_LBD	68..272	CDD:367255	53/211 (25%)
		LGIC_TM_cation	274..>374	CDD:349853	30/100 (30%)
		TM1 helix	278..298	CDD:349853	8/19 (42%)
		TM2 helix	310..338	CDD:349853	9/27 (33%)
		TM3 helix	352..374	CDD:349853	2/21 (10%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910