DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha7 and lgc-31

DIOPT Version :9

Sequence 1:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001256671.1	Gene:	lgc-31 / 184752	WormBaseID:	WBGene00008997	Length:	675	Species:	Caenorhabditis elegans

Alignment Length:	646	Identity:	148/646 - (22%)
Similarity:	249/646 - (38%)	Gaps:	161/646 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PSRSRPDNPSCPGQDRTRSMSFPQPHSLPEATANGGRMLVYGLGLLIMIPACAAGPHEK------ 62
            |:....::.|.|.....:.:. |:|:|..:...                   :|.|||:
Worm    55 PASYHTEHQSTPSHTHKKYID-PEPYSEQDEHT-------------------SAAPHEEEEELPM 99

  Fly    63 ------------------------------RLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQI 97
                                          ||...||..|....|||.:....:.:|..:.|.||
Worm   100 ERLKRAFGRNDYLLPENFKTLRRADIPVTYRLHDDLLRYYRKGTRPVTHPKKVISVSMSVFLYQI 164

  Fly    98 IDVDE-KNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTY 161
            :.:|. ||.:.::..: :|.|.|..|:||.|.:.|..::.:....:|.|:..:|.|.:.......
Worm   165 VKLDAVKNTISLSGSF-ELYWEDEFLKWNPSSYEGAEEIFLSSSDIWIPEFSLYYSLNFNDAVKL 228

  Fly   162 ATNVVVRNN--GSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTY--DGFQLDLQLQDEAG 222
            .:|..||.|  |...|..|...:|.||:|:.:||||.|:|.:.||||.:  |..:..|..|:.:
Worm   229 QSNNDVRVNYTGQVRYYIPFSSESLCKLDVKFFPFDVQQCSLLFGSWAHSNDSIKYSLYSQNLS- 292

  Fly   223 GDISSFITNGEWDLLGVPGKRNEIYYNCCPEPYID-------ITFAILIRRKTLYYFFNLIVPCV 280
              :..|..|.||:|   ....:.::.:.....|:|       |...::::|::.||.|||::|..
Worm   293 --LIDFYDNQEWEL---DTHNSSVHSDGFLYDYLDPPLFWEMIIITLVMKRQSFYYVFNLVIPST 352

  Fly   281 LIASMALLGFTLPPDSGE----KLSLGVTILLSLTVFLNMVAETMPATS-----------DAVPL 330
            :|..::::||..|..||.    |..||:..|:|::|.|..:.|.||..|           ..:||
Worm   353 MITLVSVIGFHTPSTSGRMRDAKFRLGIMTLMSMSVILLAIVEDMPKFSMGTNRRGRGSFSGIPL 417

  Fly   331 LGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECPP 395
            :|.|:..::.::..|.|:|.:.: |..|.........|    :|.||            .::..|
Worm   418 IGLYYFILLAIIGMSTVTTSMFV-YLERESRVKMNVPW----YLKWL------------SFDISP 465

  Fly   396 PPSSSSSSASGEKKQQIQNVELKERSSKSLLANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQ 460
                   |....|..:.:...:.:..|:.||:|. .:....|...|..:|:|      ...:.|.
Worm   466 -------SKIARKLSRYRPQAMSQPPSEHLLSNG-HVRSGIRDKARGVAASL------LSLLPRP 516

  Fly   461 GDD-GSVGPVGPAG--PVVDGRLH-----------EAISHTCLTSSAE-------YELAL----- 499
            |.. |:.||.|..|  |.....||           |:|......|..:       ||.||
Worm   517 GSGVGNGGPGGDNGNSPFHMQHLHAYHQDNPTPARESIRRRLSMSQYDNMLIYQYYEQALEDIAN 581

  Fly   500 -------ILKELRWITEQLKKEDETSDITRDWKFAAMVVDRL-CLIIFTLFTIIATLAVLF 552
                   .:.|:|........:|   ||...|:   .|:.|| .|.:|...:::.|...||
Worm   582 GVSRMAGSIAEIRSEMMAFLPQD---DINTKWQ---TVIRRLEILSLFFYVSVLFTTMYLF 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	138/585 (24%)
		Neur_chan_LBD	61..268	CDD:280998	61/254 (24%)
		Neur_chan_memb	275..552	CDD:280999	72/325 (22%)
lgc-31	NP_001256671.1	TM_EphA1	<43..>79	CDD:391457	4/24 (17%)
		LGIC_ECD_cation	153..339	CDD:349790	51/192 (27%)
		LGIC_TM_cation	341..>442	CDD:349853	30/101 (30%)
		TM1 helix	345..365	CDD:349853	7/19 (37%)
		Neur_chan_memb	347..634	CDD:367256	72/323 (22%)
		TM2 helix	377..398	CDD:349853	7/20 (35%)
		TM3 helix	420..442	CDD:349853	4/22 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910