Protein Alignment nAChRalpha7 and lgc-23

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_510016.2
• Gene: lgc-23 / 182622
• WormBaseID: WBGene00007594
• Length: 403
• Species: Caenorhabditis elegans
• Alignment Length: 345
• Identity: 75/345 - (21%)
• Similarity: 136/345 - (39%)
• Gaps: 67/345 - (19%)

  Fly    42 LVYGLGLLIM---IPACAAGPHEKRLLHALLDNYNSLERPVVNESD-------PLQLSFGLTLMQ 96
            :::.|.:|::   ||...:...|:...|....::..|:..|:...|       |:.:...|.|..
 Worm     1 MIFPLMILVLFNTIPIRVSEADEESERHQAYLDHRKLKEDVLGPLDGSMPSELPVFIGAQLKLDH 65

  Fly    97 IIDVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIP-----PHRLWKPDVLMYNSADEG 156
            |..||||...|...:.:|..|:|..|:|:.|.:.|....|:.     .:::|||.:.|.|:.:..
 Worm    66 ISRVDEKTGFLTLALTVKFMWSDERLQWDPSHYSGFTRTRLEFVDFWLYQIWKPRIYMTNTYERR 130

  Fly   157 FDGT--YATNVVV----RNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKF-----------G 204
            ...|  ..:|.:|    .:.|..:.....:.|:.|.:|...:|.|.|.|...|           |
 Worm   131 QSKTIDLLSNTLVEMDIHSKGFVMTTTKILLKTFCFLDFKGYPHDFQNCSFSFIPNMNANDIFLG 195

  Fly   205 S------WTYDGFQ-------LDLQLQDEAGGDISSFITNGEWDLLGVPGKRNEIYYNCCPEP-- 254
            |      :|.|...       .|.|:.|....|:..|:             ...:.::...||
 Worm   196 SSMLKAKFTKDFTDPQQVVRVQDFQINDVVTEDLYLFM-------------NRIVLHDLTREPRS 247

  Fly   255 --YIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMV 317
              ...::|.|:::||.:|....|..|.:.|.:..::...||  |...|.|.|..|:|..::.:.:
 Worm   248 LVRSFVSFTIVLQRKNVYVHLQLYAPMIFICTCLIISGFLP--SEYALPLLVFNLISEYLYFHNI 310

  Fly   318 AETMPATSDAVP---LLGTY 334
            .:.:|...|..|   |:.|:
 Worm   311 KDVLPTDFDGTPTIALIATF 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	71/325 (22%)
		Neur_chan_LBD	61..268	CDD:280998	53/252 (21%)
		Neur_chan_memb	275..552	CDD:280999	16/63 (25%)
lgc-23	NP_510016.2	Neur_chan_LBD	34..262	CDD:367255	50/240 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010