Protein Alignment nAChRalpha7 and lgc-23

DIOPT Version :10

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_510016.2
• Gene: lgc-23 / 182622
• WormBaseID: WBGene00007594
• Length: 403
• Species: Caenorhabditis elegans
• Alignment Length: 345
• Identity: 75/345 - (21%)
• Similarity: 136/345 - (39%)
• Gaps: 67/345 - (19%)

  Fly    42 LVYGLGLLIM---IPACAAGPHEKRLLHALLDNYNSLERPVVNESD-------PLQLSFGLTLMQ 96
            :::.|.:|::   ||...:...|:...|....::..|:..|:...|       |:.:...|.|..
 Worm     1 MIFPLMILVLFNTIPIRVSEADEESERHQAYLDHRKLKEDVLGPLDGSMPSELPVFIGAQLKLDH 65

  Fly    97 IIDVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIP-----PHRLWKPDVLMYNSADEG 156
            |..||||...|...:.:|..|:|..|:|:.|.:.|....|:.     .:::|||.:.|.|:.:..
 Worm    66 ISRVDEKTGFLTLALTVKFMWSDERLQWDPSHYSGFTRTRLEFVDFWLYQIWKPRIYMTNTYERR 130

  Fly   157 FDGT--YATNVVV----RNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKF-----------G 204
            ...|  ..:|.:|    .:.|..:.....:.|:.|.:|...:|.|.|.|...|           |
 Worm   131 QSKTIDLLSNTLVEMDIHSKGFVMTTTKILLKTFCFLDFKGYPHDFQNCSFSFIPNMNANDIFLG 195

  Fly   205 S------WTYDGFQ-------LDLQLQDEAGGDISSFITNGEWDLLGVPGKRNEIYYNCCPEP-- 254
            |      :|.|...       .|.|:.|....|:..|:             ...:.::...||
 Worm   196 SSMLKAKFTKDFTDPQQVVRVQDFQINDVVTEDLYLFM-------------NRIVLHDLTREPRS 247

  Fly   255 --YIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMV 317
              ...::|.|:::||.:|....|..|.:.|.:..::...||  |...|.|.|..|:|..::.:.:
 Worm   248 LVRSFVSFTIVLQRKNVYVHLQLYAPMIFICTCLIISGFLP--SEYALPLLVFNLISEYLYFHNI 310

  Fly   318 AETMPATSDAVP---LLGTY 334
            .:.:|...|..|   |:.|:
 Worm   311 KDVLPTDFDGTPTIALIATF 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	71/325 (22%)
lgc-23	NP_510016.2	Neur_chan_LBD	34..262	CDD:460752	50/240 (21%)