Protein Alignment nAChRalpha7 and lgc-4

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_509556.4
• Gene: lgc-4 / 181155
• WormBaseID: WBGene00017580
• Length: 635
• Species: Caenorhabditis elegans
• Alignment Length: 575
• Identity: 183/575 - (31%)
• Similarity: 294/575 - (51%)
• Gaps: 76/575 - (13%)

  Fly    17 QDRTRSMSFPQPH----SLPEATANGGRMLVYGLGLLIMIPACAAGPHEKRLLHALLDN--YNSL 75
            |::..|...|.||    .|.:|               :.|.....|. |:.|..:|||:  |...
 Worm    79 QEQHSSAVIPMPHFDQNRLEQA---------------LRIKGSIDGT-EEALYRSLLDHTVYEKD 127

  Fly    76 ERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPH 140
            .||.::.|.|..::||..|.||:::||:||.|.|..||.:.|.|..|.||.|.:..::.:.||..
 Worm   128 VRPCIHHSQPTNVTFGFLLNQIVEMDERNQALTTRSWLNINWMDPRLSWNESLWSEIKAIYIPHA 192

  Fly   141 RLWKPDVLMYNSA-DEGFDGTYATNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFG 204
            |:||||:::.|:| .|.:....:|:|:|.::|:..::...:|:|:|.|.:.::|||||:|::||.
 Worm   193 RIWKPDIILVNNAIREYYASLVSTDVMVTSDGNVTWLFSALFRSSCPIRVRYYPFDDQQCDLKFA 257

  Fly   205 SWTYDGFQLDLQLQDEAGGDISSFITNGEWDLLGVPGKRNEIYY-NCCPEPYIDITFAILIRRKT 268
            ||::|..:::|.|..:. ||:||::.|.|:||:.:...|..:.: :.....:..|...|.:.|:.
 Worm   258 SWSHDITEINLGLNTDK-GDLSSYMNNSEFDLVDMTAVREVVTFPSDTNSDWPIIVIRIHMHRRP 321

  Fly   269 LYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGT 333
            |:|.||.|||||||:|||:|||.:||::|||:::.:|.|||:.|:|..:.|::|.||:.|||:|.
 Worm   322 LFYVFNHIVPCVLISSMAVLGFLMPPETGEKINMIITTLLSMGVYLQSITESIPPTSEGVPLIGM 386

  Fly   334 YFNCIMFMVASSVVSTILILNYHHR---NPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECPP 395
            |:...:.||..:....::.||.|..   |...| :..|::...|.:|...:||        ....
 Worm   387 YYVSSLLMVCLATCVNVITLNMHRNGAANQGRH-VPAWMQKWILGYLATFMRM--------SIRE 442

  Fly   396 PPSSSSSSASGEKKQQIQNVE-LKERSSKSLLANVLDIDDDFRCNHRC----------------- 442
            |.|.:...||..||..|:... |::......::||.....:...|..|
 Worm   443 PDSIALLKASQSKKSTIRRSSILRDLKRVKNMSNVRAKSKEQNANRECECMDPLVHIYAESIMSC 507

  Fly   443 -ASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGRLH--EAISHTCLTSSAEYELAL--ILK 502
             |:.|.|...:..|..: ..:...:|.|     |.||.:.  .|.|::.||   |:|...  |||
 Worm   508 LAADTKPMNGSTIREDF-ASESTFLGRV-----VSDGIMPRISASSNSVLT---EFETRFRRILK 563

  Fly   503 ELRWITEQ--LKKE--DETSDITRDWKFAAMVVDRLCLIIF---TLFTIIATLAV 550
            .:....:|  :::|  ||.|.|...|:..|.|||||.|.:|   ||||||..|.|
 Worm   564 RVYRSLQQHEIREEILDERSRIQWQWQQLASVVDRLLLCLFCTATLFTIICLLIV 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	172/525 (33%)
		Neur_chan_LBD	61..268	CDD:280998	72/210 (34%)
		Neur_chan_memb	275..552	CDD:280999	98/309 (32%)
lgc-4	NP_509556.4	Neur_chan_LBD	111..321	CDD:280998	72/210 (34%)
		Neur_chan_memb	329..>457	CDD:280999	50/136 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920