Protein Alignment nAChRalpha7 and acr-16

DIOPT Version :10

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_505207.1
• Gene: acr-16 / 179235
• WormBaseID: WBGene00000055
• Length: 498
• Species: Caenorhabditis elegans
• Alignment Length: 526
• Identity: 235/526 - (44%)
• Similarity: 329/526 - (62%)
• Gaps: 42/526 - (7%)

  Fly    46 LGLLIMIPACA--AGP-----HEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEK 103
            :.:..::.:||  |.|     .|:||...|:.|||:|||||.|.|:|:.:...:.|.||||||||
 Worm     1 MSVCTLLISCAILAAPTLGSLQERRLYEDLMRNYNNLERPVANHSEPVTVHLKVALQQIIDVDEK 65

  Fly   104 NQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVR 168
            ||::..|.||...|||.||.|:.:|:|.:.|:|.|..::||||||:|||.|..||.||.||::|.
 Worm    66 NQVVYVNAWLDYTWNDYNLVWDKAEYGNITDVRFPAGKIWKPDVLLYNSVDTNFDSTYQTNMIVY 130

  Fly   169 NNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGG-DISSFITNG 232
            :.|...:|||||||.:|||||.|||||:|:|..|||||||||::||  ||...|| |||.:|:||
 Worm   131 STGLVHWVPPGIFKISCKIDIQWFPFDEQKCFFKFGSWTYDGYKLD--LQPATGGFDISEYISNG 193

  Fly   233 EWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSG 297
            ||.|.....:|||.:|:||||||.|:.|.:.:||:||||.||||:||:|...|.|||||||||:|
 Worm   194 EWALPLTTVERNEKFYDCCPEPYPDVHFYLHMRRRTLYYGFNLIMPCILTTLMTLLGFTLPPDAG 258

  Fly   298 EKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDT 362
            ||::|.:|:|||:..||::|:|..|.||:||||||.:|.|.|.:|.:|.|.|:.:||.|:|.|:|
 Worm   259 EKITLQITVLLSICFFLSIVSEMSPPTSEAVPLLGIFFTCCMIVVTASTVFTVYVLNLHYRTPET 323

  Fly   363 HEMSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKERSSKSLLA 427
            |:|..|.|.:.|||:|.||||:|||. .......||..|:..:...:..|:|::..|.|    |:
 Worm   324 HDMGPWTRNLLLYWIPWILRMKRPGH-NLTYASLPSLFSTKPNRHSESLIRNIKDNEHS----LS 383

  Fly   428 NVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGRLHEAISHTCLTSS 492
            .....|.|.|.|.            |..|........|:|.: |:         ..||....|:.
 Worm   384 RANSFDADCRLNQ------------YIMTQSVSNGLTSLGSI-PS---------TMISSNGTTTD 426

  Fly   493 AEYELALIL-----KELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLF 552
            ...:..|::     .||:.:|:::.:.|:......:|||||||||||||.:||:|.|::|:.:.:
 Worm   427 VSQQATLLILHRIYHELKIVTKRMIEGDKEEQACNNWKFAAMVVDRLCLYVFTIFIIVSTIGIFW 491

  Fly   553 SAPHFI 558
            |||:.:
 Worm   492 SAPYLV 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	228/499 (46%)
acr-16	NP_505207.1	LIC	6..493	CDD:455710	232/515 (45%)
		LGIC_ECD_nAChR	48..228	CDD:349798	99/181 (55%)
		Cys-loop	147..161	CDD:349798	11/13 (85%)