Protein Alignment nAChRalpha7 and acr-16

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_505207.1
• Gene: acr-16 / 179235
• WormBaseID: WBGene00000055
• Length: 498
• Species: Caenorhabditis elegans
• Alignment Length: 526
• Identity: 235/526 - (44%)
• Similarity: 329/526 - (62%)
• Gaps: 42/526 - (7%)

  Fly    46 LGLLIMIPACA--AGP-----HEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEK 103
            :.:..::.:||  |.|     .|:||...|:.|||:|||||.|.|:|:.:...:.|.||||||||
 Worm     1 MSVCTLLISCAILAAPTLGSLQERRLYEDLMRNYNNLERPVANHSEPVTVHLKVALQQIIDVDEK 65

  Fly   104 NQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVR 168
            ||::..|.||...|||.||.|:.:|:|.:.|:|.|..::||||||:|||.|..||.||.||::|.
 Worm    66 NQVVYVNAWLDYTWNDYNLVWDKAEYGNITDVRFPAGKIWKPDVLLYNSVDTNFDSTYQTNMIVY 130

  Fly   169 NNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGG-DISSFITNG 232
            :.|...:|||||||.:|||||.|||||:|:|..|||||||||::||  ||...|| |||.:|:||
 Worm   131 STGLVHWVPPGIFKISCKIDIQWFPFDEQKCFFKFGSWTYDGYKLD--LQPATGGFDISEYISNG 193

  Fly   233 EWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSG 297
            ||.|.....:|||.:|:||||||.|:.|.:.:||:||||.||||:||:|...|.|||||||||:|
 Worm   194 EWALPLTTVERNEKFYDCCPEPYPDVHFYLHMRRRTLYYGFNLIMPCILTTLMTLLGFTLPPDAG 258

  Fly   298 EKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDT 362
            ||::|.:|:|||:..||::|:|..|.||:||||||.:|.|.|.:|.:|.|.|:.:||.|:|.|:|
 Worm   259 EKITLQITVLLSICFFLSIVSEMSPPTSEAVPLLGIFFTCCMIVVTASTVFTVYVLNLHYRTPET 323

  Fly   363 HEMSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKERSSKSLLA 427
            |:|..|.|.:.|||:|.||||:|||. .......||..|:..:...:..|:|::..|.|    |:
 Worm   324 HDMGPWTRNLLLYWIPWILRMKRPGH-NLTYASLPSLFSTKPNRHSESLIRNIKDNEHS----LS 383

  Fly   428 NVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGRLHEAISHTCLTSS 492
            .....|.|.|.|.            |..|........|:|.: |:         ..||....|:.
 Worm   384 RANSFDADCRLNQ------------YIMTQSVSNGLTSLGSI-PS---------TMISSNGTTTD 426

  Fly   493 AEYELALIL-----KELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLF 552
            ...:..|::     .||:.:|:::.:.|:......:|||||||||||||.:||:|.|::|:.:.:
 Worm   427 VSQQATLLILHRIYHELKIVTKRMIEGDKEEQACNNWKFAAMVVDRLCLYVFTIFIIVSTIGIFW 491

  Fly   553 SAPHFI 558
            |||:.:
 Worm   492 SAPYLV 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	228/499 (46%)
		Neur_chan_LBD	61..268	CDD:280998	115/207 (56%)
		Neur_chan_memb	275..552	CDD:280999	107/281 (38%)
acr-16	NP_505207.1	LIC	6..493	CDD:273305	232/515 (45%)
		Neur_chan_LBD	23..229	CDD:280998	115/207 (56%)
		Neur_chan_memb	236..490	CDD:280999	107/280 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	261	1.000	Domainoid score	I1050
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	470	1.000	Inparanoid score	I838
Isobase	1	0.950	-	0	Normalized mean entropy	S3299
OMA	1	1.010	-	-		QHG45242
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	1	1.000	-	-		mtm4815
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3025
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.960