Protein Alignment nAChRalpha7 and lgc-26

DIOPT Version :10

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_503167.1
• Gene: lgc-26 / 178554
• WormBaseID: WBGene00021981
• Length: 486
• Species: Caenorhabditis elegans
• Alignment Length: 357
• Identity: 90/357 - (25%)
• Similarity: 145/357 - (40%)
• Gaps: 51/357 - (14%)

  Fly    46 LGLLIMI---PACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLL 107
            :|:||..   .|.:....|::|...||..|||..|||..||...|::..|.:..:..|||..|..
 Worm     9 IGVLINFHFGNAASQSTDERKLEAQLLKGYNSKVRPVKVESTVTQVAVYLNIAHVEKVDEHEQTA 73

  Fly   108 ITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNV--VVRNN 170
            :.:..|...|.|..|:| ..:...:..|.|...:||:|.:.:||||.......|.|.:  :|.|.
 Worm    74 LVHGHLMASWTDEYLKW-ERKATNISTLSIASSKLWQPALQLYNSARGNSWSLYLTGLPAIVYNT 137

  Fly   171 GSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFI------ 229
            |.........|..||:.|.|.:|:|.|.|.:....|.|...|::|.....|.|.....|
 Worm   138 GKVWSRGTFSFFVTCQFDFTNWPYDQQSCPIVITDWVYGLGQVNLSDPATAAGYGKPTIRLSYDP 202

  Fly   230 ---TN----GEWDLLGVPGKRNEIYYNCCPEPYID-------------ITFAILIRRKTLYYFFN 274
               ||    |.|::  :...:...|:.  |:..:|             :.|.|.::|...|:...
 Worm   203 IDETNKRHVGGWEV--IDSWKKHCYWG--PKGCLDAEPDGNPDWYWSLLEFGITLKRHLPYFSLT 263

  Fly   275 LIVPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIM 339
            :::|.|..:.|.||||.:.........:.:.|.|..|...|:::. ||..|...|.:...::..:
 Worm   264 IVMPMVSTSLMILLGFWIENFDFNVFLITLNIALQATYGSNILSR-MPPGSGRTPKIVHLYSIGL 327

  Fly   340 FMVASSVVSTILILNYHHRNPDTHEMSEWIRV 371
            .:.|..||..:              ||.::||
 Worm   328 LISAFQVVLIV--------------MSNFLRV 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	86/341 (25%)
lgc-26	NP_503167.1	LGIC_ECD_cation	52..256	CDD:349790	50/208 (24%)
		Cys-loop	152..166	CDD:349790	6/13 (46%)