Protein Alignment nAChRalpha7 and lgc-10

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001293778.1
• Gene: lgc-10 / 177409
• WormBaseID: WBGene00022247
• Length: 450
• Species: Caenorhabditis elegans
• Alignment Length: 320
• Identity: 85/320 - (26%)
• Similarity: 152/320 - (47%)
• Gaps: 16/320 - (5%)

  Fly    64 LLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWNSSE 128
            :|:.:...|:....|.|  ..|:.::..:.|..:|::.|..||....|.....|.|..|.|:.|:
 Worm    30 ILNDIFVGYDRRVLPFV--QGPVLVNMTIVLGILIELKENQQLAAYVISHTQRWYDGRLSWDPSK 92

  Fly   129 FGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVR--NNGSCLYVPPGIFKSTCKIDITW 191
            :.|.|::.:|...:|.|.:.:|||. |..|........||  :||......|...::.|:|....
 Worm    93 YRGQREVIVPQTMVWIPKLFVYNSL-ESKDMLTENRADVRLYHNGRIKINIPQYVQAICRIQTES 156

  Fly   192 FPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGEWDLLGVPGKRNEIYYNCCPEPYI 256
            ||||.|.|.:...|...:..::.:........  |.|..|.||.|..|..:  .:.:....|..:
 Worm   157 FPFDCQFCAVALASPLLNVNEMVVNATQPPRD--SYFSGNAEWYLFNVTVR--HMTFEEEGESRV 217

  Fly   257 DITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDS----GEKLSLGVTILLSLTVFLNMV 317
            :|.:...::|:.:||...::.|..||:::::||...|..:    .||:|||:..||::||.|.:|
 Worm   218 EIHYVFHLQRRPIYYITVIVAPTFLISALSILGIFSPGSNDGPRNEKVSLGLGSLLAMTVLLGIV 282

  Fly   318 AETMPATSDAVPLLGTYFNCIMFMVASSVVSTILIL--NYHHRNPDTHEMSEWIRVIFLY 375
            |..||.::| :||||.|...::.:.|.:|..:::.|  ..|:...:.......:|.:||:
 Worm   283 AGAMPKSND-IPLLGYYILAVIVLCAVAVAISMMFLAVTRHYIQKEQMPSKRILRFLFLH 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	85/320 (27%)
		Neur_chan_LBD	61..268	CDD:280998	50/205 (24%)
		Neur_chan_memb	275..552	CDD:280999	33/107 (31%)
lgc-10	NP_001293778.1	Neur_chan_LBD	28..229	CDD:280998	50/205 (24%)
		Neur_chan_memb	236..>342	CDD:280999	33/107 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010