DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha7 and eat-2

DIOPT Version :9

Sequence 1:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_496959.1	Gene:	eat-2 / 175072	WormBaseID:	WBGene00001133	Length:	474	Species:	Caenorhabditis elegans

Alignment Length:	524	Identity:	179/524 - (34%)
Similarity:	283/524 - (54%)	Gaps:	78/524 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 RMLVYGLGLLIMIPACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKN 104
            ::..:.|.||:.|....:...|.|||..|.:.|:.:||||.:...|:.:...|.|.|::||||:|
Worm     4 KIAFFTLILLVSIERVYSSDEEYRLLKDLREGYDPVERPVADHRKPVNVKLRLILQQLVDVDERN 68

  Fly   105 QLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRN 169
            |::...:|.:..|||..|||:..|:|.:..|:||...|||||:|::|||:|.||.::..::||.:
Worm    69 QVITLVVWNQYTWNDYKLRWSPEEYGNITTLQIPHGTLWKPDILLFNSANEHFDASFPVHMVVSS 133

  Fly   170 NGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDE--AGG---DISSFI 229
            ||..|:.||||...:|.:.:||||:|.|.|.:||||||| |.:||||:.|.  ..|   |:..:|
Worm   134 NGDVLFAPPGIVSFSCSLSMTWFPYDQQVCYLKFGSWTY-GKKLDLQIDDSDLPDGHKMDLQYYI 197

  Fly   230 TNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPP 294
            .|||:|||..|..|....:  ..|.|:::.|.:.::|:|:||..|.|||.:||:...:||||:||
Worm   198 PNGEFDLLATPAFRKSTTF--LDETYVELYFHMHLKRRTMYYGLNWIVPSILISLSNILGFTMPP 260

  Fly   295 DSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRN 359
            :.|||::|.:|..||:.|||.||:|..|.||:::|::..:|:..:.::..|:.::::|:|...|:
Worm   261 ECGEKITLQITNFLSVMVFLAMVSEVAPPTSESIPIIAAFFSLSIVILGLSICASLIIVNIFFRH 325

  Fly   360 PDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECPP--PPSSSSSSASGEKKQQIQNVELKERSS 422
            |.||.|.:|.|.:||.|||..|.|.||...  .|.|  ....:...|.|:..:.::|.:.:.|
Worm   326 PKTHRMGDWTRYVFLEWLPWFLLMSRPEHT--FCRPRREEEKNDEEAGGDGTKLLENQQHQPR-- 386

  Fly   423 KSLLAN---VLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGRLHEAI 484
            ..||.|   |:|             :|:|:                              |.|.|
Worm   387 PRLLVNSQLVMD-------------STVPY------------------------------LEEII 408

  Fly   485 SHTCLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLA 549
            .:                 |:....:|..::|..:...:|:|.|||:|||.|.:|| ..|..|.|
Worm   409 GY-----------------LKVFKAKLDDDEEEEEEILNWRFMAMVIDRLSLFLFT-GLIFGTTA 455

  Fly   550 VLFS 553
            ::|:
Worm   456 LIFA 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	172/498 (35%)
		Neur_chan_LBD	61..268	CDD:280998	89/211 (42%)
		Neur_chan_memb	275..552	CDD:280999	81/281 (29%)
eat-2	NP_496959.1	LIC	3..459	CDD:273305	178/522 (34%)
		Neur_chan_LBD	25..234	CDD:280998	89/211 (42%)
		Neur_chan_memb	242..456	CDD:280999	80/278 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45242
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.890