DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha7 and acr-7

DIOPT Version :9

Sequence 1:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_495647.1	Gene:	acr-7 / 174262	WormBaseID:	WBGene00000046	Length:	538	Species:	Caenorhabditis elegans

Alignment Length:	514	Identity:	201/514 - (39%)
Similarity:	283/514 - (55%)	Gaps:	50/514 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 EKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWN 125
            |.:|...||.||:.|.|||.|....|.::..:.:.|::.||.|:|::..|.|||..|.|..||||
Worm    31 EAQLYRDLLTNYSYLVRPVRNPKKALTVTMKVFIQQVLLVDAKHQMIEVNAWLKYIWTDFRLRWN 95

  Fly   126 SSEFGGVRDLRIP-PHRLWKPDVLMYN----SADEGFDGTYATNVVVRNNGSCLYVPPGIFKSTC 185
            ..::..:..:|.. ..::|:||:|:||    ...|.||.||.||.|..::|...::||||||.:|
Worm    96 PLDYENITSVRFQGEDQIWQPDILLYNRYIEDEQESFDITYKTNAVAYSDGVINWIPPGIFKLSC 160

  Fly   186 KIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQ----DEAGGDISSFITNGEWDLLGVPGKRNEI 246
            |:|||.||||:|.|.||||||||.||.|||:|.    .|...|:|::||||||.||..|.:|.|.
Worm   161 KMDITLFPFDEQICFMKFGSWTYHGFALDLRLDVVKGQEPSADLSTYITNGEWHLLSAPARREEK 225

  Fly   247 YYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLP-PDSGEKLSLGVTILLSL 310
            :|.||.|||..:.|.:.:||:|.||.||:::|.:|::.|:||.|.|| .|..||:.|..|||||:
Worm   226 FYKCCKEPYPTVKFYLHLRRRTFYYVFNVVLPTLLVSFMSLLAFCLPATDLSEKIGLQTTILLSV 290

  Fly   311 TVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFLY 375
            ..||.:::|..|.||:||||||.:|:.:.|:||.|...|||:||..:|....|.:|...|.|||.
Worm   291 CFFLTILSEMTPTTSEAVPLLGVFFSALTFIVAMSTTFTILVLNIRYRQITNHYLSPMFRSIFLE 355

  Fly   376 WLPCILRMQRPG---QVGYECPPPPSSSSSSASGEKKQQIQNVELKERSSKSLLANVLDIDDDFR 437
            .||.::.|:||.   :.|       ||...|::.:..|..:|.||     ||:|... |......
Worm   356 CLPWLMMMKRPDHKFRRG-------SSYRDSSADQCVQCAKNAEL-----KSILRGT-DNQQQIE 407

  Fly   438 CNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGRLHEAISH---TCLTSSAE--YEL 497
            .|      |....||...::.|:..||..  :.....:.:....|..:|   .|..|..|  .||
Worm   408 TN------TFYPFPTETLSLNRKVGDGLF--IQRRCQIHEEARSEKFTHGMLACEKSLRENGSEL 464

  Fly   498 ALIL-----------KELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTII 545
            |.||           .::..|.:::..:.:..||..:|||||..|||.||||||:..||
Worm   465 ANILVTILKMYEVMVSQVERIRKRIALKRKRKDIQDEWKFAAQAVDRFCLIIFTIVFII 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	201/514 (39%)
		Neur_chan_LBD	61..268	CDD:280998	97/215 (45%)
		Neur_chan_memb	275..552	CDD:280999	99/291 (34%)
acr-7	NP_495647.1	LIC	28..524	CDD:273305	201/514 (39%)
		Neur_chan_LBD	31..247	CDD:280998	97/215 (45%)
		Neur_chan_memb	254..524	CDD:280999	99/291 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880