Protein Alignment nAChRalpha7 and CHRNE

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_000071.1
• Gene: CHRNE / 1145
• HGNCID: 1966
• Length: 493
• Species: Homo sapiens
• Alignment Length: 530
• Identity: 146/530 - (27%)
• Similarity: 261/530 - (49%)
• Gaps: 77/530 - (14%)

  Fly    46 LGLLIMIPACAAG---PHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLL 107
            ||:|:::.....|   ..|.||.|.|.:||:...|||....|.:.:|..:||..:|.::||.:.|
Human     6 LGVLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETL 70

  Fly   108 ITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGS 172
            .|::|:.::|.|..|.::..:|||:..||:|...:|.|::::.|:.|..|...|..||:|...||
Human    71 TTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGS 135

  Fly   173 CLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGG--------DISSFI 229
            ..::||.|::|.|.:::|:||||.|.|.:.|.|.||:..:::.....:..|        |..::.
Human   136 VTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYT 200

  Fly   230 TNGEWDLLGVPGKRNEIYYNCCPEP-YIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLP 293
            .||||.:...||.....:......| ..|:.::::||||.|:|..|:|||||||:.:.||.:.||
Human   201 ENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLP 265

  Fly   294 PDS-GEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHH 357
            ..: |:|.::.:.:||:.||||.::|:.:|.||.:|||||.:...:|.:....|::.:::||...
Human   266 AQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQ 330

  Fly   358 RNPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKERSS 422
            |.|.||.||..:|.:.|..||.:|          ..||||.:..:::   ..::..:|.|..|:.
Human   331 RTPTTHAMSPRLRHVLLELLPRLL----------GSPPPPEAPRAAS---PPRRASSVGLLLRAE 382

  Fly   423 KSLLANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVV-DGRLHEAISH 486
            :.:|..                                          |...:| :|:.|...:.
Human   383 ELILKK------------------------------------------PRSELVFEGQRHRQGTW 405

  Fly   487 T---CLT-SSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLC----LIIFTLFT 543
            |   |.: .:|..|:...:..:.::.|..:.::.|.:...||......:|.:|    |::|::.:
Human   406 TAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGS 470

  Fly   544 IIATLAVLFS 553
            .:..|...|:
Human   471 SLIFLGAYFN 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	140/507 (28%)
		Neur_chan_LBD	61..268	CDD:280998	69/215 (32%)
		Neur_chan_memb	275..552	CDD:280999	68/286 (24%)
CHRNE	NP_000071.1	LIC	21..475	CDD:273305	140/508 (28%)
		Neur_chan_LBD	24..240	CDD:280998	69/215 (32%)
		Neur_chan_memb	247..474	CDD:280999	67/281 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910