DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha7 and CHRND

DIOPT Version :9

Sequence 1:NP_001162795.1 Gene:nAChRalpha7 / 32928 FlyBaseID:FBgn0086778 Length:564 Species:Drosophila melanogaster
Sequence 2:NP_000742.1 Gene:CHRND / 1144 HGNCID:1965 Length:517 Species:Homo sapiens


Alignment Length:528 Identity:167/528 - (31%)
Similarity:260/528 - (49%) Gaps:70/528 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 VYGLGLLIMIPACAAG--PHEKRLLHALLD--NYNSLERPVVNESDPLQLSFGLTLMQIIDVDEK 103
            |..||||..:..|.:.  ..|:||:..|..  .||...|||.::.:.:.::..|||..:|.:.|.
Human     5 VLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEV 69

  Fly   104 NQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVR 168
            .:.|.||:|::..|.|..|:||:.|||.:..||:||..:|.|::::.|:.|..|..:|:.||:|.
Human    70 EETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVY 134

  Fly   169 NNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGG---------- 223
            :.|...::||.||:|:|.|.:|:||||.|.|.:||.|..|...::.|.|:.:|..          
Human   135 HYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWII 199

  Fly   224 -DISSFITNGEWDLLGVPGKRNEIYYNCCPEPYI------DITFAILIRRKTLYYFFNLIVPCVL 281
             |...|..||||:::..|.:     .|..|...:      ||||.::||||.|:|..|::|||||
Human   200 IDPEGFTENGEWEIVHRPAR-----VNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVL 259

  Fly   282 IASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSV 346
            |:.|..|.|.||.|||||.|:.:::||:.:|||.::::.:||||.|:||:|.:....|.:|...|
Human   260 ISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVV 324

  Fly   347 VSTILILNYHHRNPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSS--SSSSASGEKK 409
            |..:::||.|.|.|.||.:||.::.:||..||.:|.|.||.:.|    |.|.:  ..||:.|...
Human   325 VICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDG----PSPGALVRRSSSLGYIS 385

  Fly   410 QQIQNVELKERSSKSLLANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGP 474
            :..:...||.||             |.....:.....|..:.|..|......:...........|
Human   386 KAEEYFLLKSRS-------------DLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKP 437

  Fly   475 VVDGRLHEAISHTCLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIF 539
            .|||                         ..:|...::.::..::....|...|..||||||.:.
Human   438 AVDG-------------------------ANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVV 477

  Fly   540 TLFTIIAT 547
            |...::.|
Human   478 TPVMVVGT 485

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha7NP_001162795.1 LIC 59..548 CDD:273305 161/510 (32%)
Neur_chan_LBD 61..268 CDD:280998 77/225 (34%)
Neur_chan_memb 275..552 CDD:280999 80/275 (29%)
CHRNDNP_000742.1 Neur_chan_LBD 25..246 CDD:308532 77/225 (34%)
Neur_chan_memb 253..489 CDD:308533 80/275 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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