Protein Alignment nAChRalpha7 and Chrna4

DIOPT Version :10

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_056545.3
• Gene: Chrna4 / 11438
• MGIID: 87888
• Length: 629
• Species: Mus musculus
• Alignment Length: 628
• Identity: 205/628 - (32%)
• Similarity: 301/628 - (47%)
• Gaps: 135/628 - (21%)

  Fly    41 MLVYGLGLLIMIPACAAGPH-------EKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQII 98
            :|:.|.|||      .|..|       |:|||..|...||...|||.|.||.:.:.|||::.|:|
Mouse    18 LLLLGTGLL------PASSHIETRAHAEERLLKRLFSGYNKWSRPVANISDVVLVRFGLSIAQLI 76

  Fly    99 DVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYAT 163
            |||||||::.||:|:|.||:|..|||:..::..|..:|||...:|:||:::||:||..|..|:.|
Mouse    77 DVDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLT 141

  Fly   164 NVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSF 228
            ...:..:|...:.||.|:||:|.||:|:||||.|.|.|||||||||..::|| :...:..|...|
Mouse   142 KAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDL-VSMHSRVDQLDF 205

  Fly   229 ITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLP 293
            ..:|||.::...|..|...|.||.|.|.|||:|.:|||..|:|..|||:||:||:.:.:|.|.||
Mouse   206 WESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFIIRRLPLFYTINLIIPCLLISCLTVLVFYLP 270

  Fly   294 PDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHR 358
            .:.|||::|.:::||||||||.::.|.:|:||..:||:|.|....|..|..|:|.|:.:||.|||
Mouse   271 SECGEKVTLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHR 335

  Fly   359 NPDTHEMSEWIRVIFLYWLPCILRMQRPGQV---------------------------------- 389
            :|.||.|..|:|.:||..:|.:|.|:||..|
Mouse   336 SPRTHTMPAWVRRVFLDIVPRLLFMKRPSVVKDNCRRLIESMHKMANAPRFWPEPESEPGILGDI 400

  Fly   390 ------------------------------------------GYECPPPPSSSSSSASG------ 406
                                                      ...||.|.|....::||
Mouse   401 CNQGLSPAPTFCNRMDTAVETQPTCRSPSHKVPDLKTSEVEKASPCPSPGSCHPPNSSGAPVLIK 465

  Fly   407 EKKQQIQNVELKERSSKSLLANVLDIDDDFRCNHR----CAS----ATLPH-----QPTYYRTMY 458
            .:...:|:|...:.::          :...||..|    |.|    |:|..     .|...:|..
Mouse   466 ARSLSVQHVPSSQEAA----------EGSIRCRSRSIQYCVSQDGAASLTESKPTGSPASLKTRP 520

  Fly   459 RQ---GDDGS--------VGPVGPAGPVVDGRLHEAISHTCLTSSAEYELALILKELRWITEQLK 512
            .|   .|..|        ..||.|...:..|.......|..|:.:    |...::.:::|.:.||
Mouse   521 SQLPVSDQTSPCKCTCKEPSPVSPITVLKAGGTKAPPQHLPLSPA----LTRAVEGVQYIADHLK 581

  Fly   513 KEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLFSAP 555
            .||....:..|||:.|||:||:.|.:|.:..::.|:. ||..|
Mouse   582 AEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVG-LFLPP 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	195/601 (32%)
Chrna4	NP_056545.3	LGIC_ECD	39..245	CDD:475126	95/206 (46%)
		Neur_chan_memb	252..620	CDD:460753	97/382 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..459		4/38 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	503..529		5/25 (20%)