Protein Alignment nAChRalpha7 and CHRNB1

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_000738.2
• Gene: CHRNB1 / 1140
• HGNCID: 1961
• Length: 501
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 177/547 - (32%)
• Similarity: 273/547 - (49%)
• Gaps: 89/547 - (16%)

  Fly    41 MLVYGLGLLIMIPACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQ 105
            ||:..|| ..:.|.......|.||...|...|:|..||.....|.:::|.||.|.|:|.::||::
Human     8 MLLGALG-APLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDE 71

  Fly   106 LLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNN 170
            .:.|.::|.|||.|..|.|:.:|..|:..|||....:|.|||::.|:.|..||.....:|||.::
Human    72 EMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSD 136

  Fly   171 GSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQ--LQDEAGG--DI----SS 227
            ||..:.||||::|:|.|.:|:||||.|.|.|.|.|::||..::.||  |..:..|  :|    .:
Human   137 GSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGT 201

  Fly   228 FITNGEWDLLGVP---------------GKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIV 277
            ||.||:|:::..|               |:|.|            :.|.::||||.|:|..|:|.
Human   202 FIENGQWEIIHKPSRLIQPPGDPRGGREGQRQE------------VIFYLIIRRKPLFYLVNVIA 254

  Fly   278 PCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMV 342
            ||:||..:|:..|.||||:|||:.|.:..||:|||||.::|:.:|.||.:||::..|....|.:|
Human   255 PCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLV 319

  Fly   343 ASSVVSTILILNYHHRNPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSSSSSSASGE 407
            ..||:.::::||.|||:|.||:|..|:|.||::.||..||::||.......|.||..||..:...
Human   320 TFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPKPERDLMPEPPHCSSPGSGWG 384

  Fly   408 KKQQIQNVELKERSSKSLLANVLDIDDDFRCNHRCASATLP----HQPTYYRTMYRQGDDGSVGP 468
            :.                       .|::......:....|    .||.......|:..||....
Human   385 RG-----------------------TDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFIDGPNRA 426

  Fly   469 VG--PAGPVVDGRLHEAISHTCLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVV 531
            |.  |                        ||..::..:.:|..||:::::...:..||:|.||||
Human   427 VALLP------------------------ELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVV 467

  Fly   532 DRLCLIIFTLFTIIATLAVLFSAPHFI 558
            |||.|..|.:||.:.||.:...|.:.:
Human   468 DRLFLWTFIIFTSVGTLVIFLDATYHL 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	169/517 (33%)
		Neur_chan_LBD	61..268	CDD:280998	80/229 (35%)
		Neur_chan_memb	275..552	CDD:280999	87/282 (31%)
CHRNB1	NP_000738.2	Neur_chan_LBD	27..245	CDD:308532	80/229 (35%)
		Neur_chan_memb	252..487	CDD:308533	87/281 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910