DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha7 and CHRNA4

DIOPT Version :9

Sequence 1:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_000735.1	Gene:	CHRNA4 / 1137	HGNCID:	1958	Length:	627	Species:	Homo sapiens

Alignment Length:	647	Identity:	210/647 - (32%)
Similarity:	312/647 - (48%)	Gaps:	153/647 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PHSLPEATANGGRMLVYGLGLLIMIPACAAGPH-------EKRLLHALLDNYNSLERPVVNESDP 85
            |..||..      :|:.|.|||      .|..|       |:|||..|...||...|||.|.||.
Human     9 PRLLPPL------LLLLGTGLL------RASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDV 61

  Fly    86 LQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMY 150
            :.:.|||::.|:||||||||::.||:|:|.||:|..|||:.:::..|..:|||...:|:||:::|
Human    62 VLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLY 126

  Fly   151 NSADEGFDGTYATNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDL 215
            |:||..|..|:.|...:.::|...:.||.|:||:|.||:|:||||.|.|.|||||||||..::||
Human   127 NNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDL 191

  Fly   216 QLQDEAGGDISSFITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCV 280
             :...:..|...|..:|||.::...|..|...|.||.|.|.|||:|.:|||..|:|..|||:||:
Human   192 -VNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCL 255

  Fly   281 LIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASS 345
            ||:.:.:|.|.||.:.|||::|.:::||||||||.::.|.:|:||..:||:|.|....|..|..|
Human   256 LISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLS 320

  Fly   346 VVSTILILNYHHRNPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYEC----------------- 393
            :|.|:.:||.|||:|.||.|..|:|.:||..:|.:|.|:||..|...|
Human   321 IVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFW 385

  Fly   394 ------PP---------PPSSS-------------SSSASGEKKQQIQNVELKERS--------- 421
                  ||         |||.|             |..:..::....|.:|.::.|
Human   386 PEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCR 450

  Fly   422 ------------SKSLLANVLD-----IDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPV 469
                        ::||....:.     ::...||..|.....:|.            ||
Human   451 PPHGTQAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPR------------DD------ 497

  Fly   470 GPAGPVVDGRLHEAISH-------------------TC------LTSSAEYE------------- 496
              |.|..||:...|::.                   ||      ::.||..:
Human   498 --AAPEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPL 560

  Fly   497 ---LALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLFSAP 555
               |...::.:::|.:.||.||....:..|||:.|||:||:.|.:|.:..::.|:. ||..|
Human   561 SPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVG-LFLPP 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	197/607 (32%)
		Neur_chan_LBD	61..268	CDD:280998	95/206 (46%)
		Neur_chan_memb	275..552	CDD:280999	99/388 (26%)
CHRNA4	NP_000735.1	Neur_chan_LBD	37..243	CDD:280998	95/206 (46%)
		Neur_chan_memb	250..618	CDD:280999	99/388 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..481		12/98 (12%)
		Ten_N	<423..>572	CDD:284015	21/168 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..561		11/72 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910