Protein Alignment nAChRalpha7 and CHRNA3

DIOPT Version :10

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_000734.2
• Gene: CHRNA3 / 1136
• HGNCID: 1957
• Length: 505
• Species: Homo sapiens
• Alignment Length: 535
• Identity: 199/535 - (37%)
• Similarity: 307/535 - (57%)
• Gaps: 48/535 - (8%)

  Fly    28 PHSLPEATANGGRMLVYGLGLLIMIPACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGL 92
            |.|||.| .:..|:|:  |.||.::|...|...|.||...|.::||.:.|||.|.|||:.:.|.:
Human     5 PLSLPLA-LSPPRLLL--LLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEV 66

  Fly    93 TLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGF 157
            ::.|::.|||.||::.||:|||..|||..|:||.|::||...:|:|..::||||:::||:|...|
Human    67 SMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDF 131

  Fly   158 DGTYATNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAG 222
            .....|..:::..|...::||.||||:||||:|:||||.|.|.||||||:||..::||.|.. :.
Human   132 QVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIG-SS 195

  Fly   223 GDISSFITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMAL 287
            .::..:..:|||.::..||.:::|.||||.|.|.|||:::.|||..|:|..|||:||:||:.:.:
Human   196 MNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTV 260

  Fly   288 LGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILI 352
            |.|.||.|.|||::|.:::||||||||.::.||:|:||..:||:|.|....|..|..|:|.|:.:
Human   261 LVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFV 325

  Fly   353 LNYHHRNPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVEL 417
            ||.|:|.|.||.|..|::.:||..||.::.|.||             :|:..:.:|.:.:...||
Human   326 LNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRP-------------TSNEGNAQKPRPLYGAEL 377

  Fly   418 K-----ERSSKSLLANVLDIDDDF--RCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPV 475
            .     .|:............|..  .|:||....:     .:...:.|.....||..|
Human   378 SNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKIS-----NFSANLTRSSSSESVDAV------ 431

  Fly   476 VDGRLHEAISHTCLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFT 540
                    :|.:.|:.    |:...::.:::|.|.:|.::|..:|..|||:.|||:||:.|.:||
Human   432 --------LSLSALSP----EIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFT 484

  Fly   541 LFTIIATLAVLFSAP 555
            |..|:.| |.||..|
Human   485 LVCILGT-AGLFLQP 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	182/495 (37%)
CHRNA3	NP_000734.2	LIC	30..496	CDD:455710	186/503 (37%)
		LGIC_ECD_nAChR_A3	35..241	CDD:349817	92/206 (45%)
		Cys-loop	159..173	CDD:349817	10/13 (77%)