DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nAChRalpha7 and CHRNA1

DIOPT Version :9

Sequence 1:NP_001162795.1 Gene:nAChRalpha7 / 32928 FlyBaseID:FBgn0086778 Length:564 Species:Drosophila melanogaster
Sequence 2:XP_016858745.1 Gene:CHRNA1 / 1134 HGNCID:1955 Length:489 Species:Homo sapiens


Alignment Length:536 Identity:177/536 - (33%)
Similarity:287/536 - (53%) Gaps:106/536 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 LIMIPACAAG-----PHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLI 108
            :::..|.:||     .||.||:..|..:|:|:.|||.:....::::.||.|:|:|:|||.||::.
Human    14 VLVSSAVSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVT 78

  Fly   109 TNIWLKL-------------------------EWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVL 148
            ||:.||.                         :|.|.||:||..::|||:.:.||..::|:||::
Human    79 TNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLV 143

  Fly   149 MYNSADEGFDGTYATNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQL 213
            :||:||..|.....|.|:::..|...:.||.||||.|:|.:|.||||:|.|.||.|:|||||..:
Human   144 LYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVV 208

  Fly   214 DLQLQDEAGGDISSFITNGEWDLLGVPGKRNEIYYNCCPE-PYIDITFAILIRRKTLYYFFNLIV 277
            .:..:.:. .|:|:|:.:|||.:....|.::.:.|:|||: ||:|||:..:::|..||:..|:|:
Human   209 AINPESDQ-PDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVII 272

  Fly   278 PCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMV 342
            ||:|.:.:..|.|.||.|||||::|.:::||||||||.::.|.:|:||.||||:|.|....|..|
Human   273 PCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFV 337

  Fly   343 ASSVVSTILILNYHHRNPDTHEMSEWIRVIFLYWLPCIL---RMQRPGQVGYECPPPPSSSSSSA 404
            .:|::.|::::|.|||:|.||.|..|:|.:|:..:|.|:   .|:||.                 
Human   338 IASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPS----------------- 385

  Fly   405 SGEKKQQIQNVELKERSSKSLLANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPV 469
                         :|:..|.:....:||.|                           ..|..|| 
Human   386 -------------REKQDKKIFTEDIDISD---------------------------ISGKPGP- 409

  Fly   470 GPAGPVVDGRLHEAISHTCLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRL 534
            .|.|           .|:.|....|.:.|  ::.:::|.|.:|.:.|:::...:||:.|||:|.:
Human   410 PPMG-----------FHSPLIKHPEVKSA--IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHI 461

  Fly   535 CLIIFTLFTIIATLAV 550
            .|.:|.|..||.||||
Human   462 LLGVFMLVCIIGTLAV 477

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha7NP_001162795.1 LIC 59..548 CDD:273305 170/517 (33%)
Neur_chan_LBD 61..268 CDD:280998 85/232 (37%)
Neur_chan_memb 275..552 CDD:280999 85/279 (30%)
CHRNA1XP_016858745.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.