Protein Alignment nAChRalpha7 and Chrna5

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001360830.1
• Gene: Chrna5 / 110835
• MGIID: 87889
• Length: 467
• Species: Mus musculus
• Alignment Length: 533
• Identity: 181/533 - (33%)
• Similarity: 273/533 - (51%)
• Gaps: 105/533 - (19%)

  Fly    32 PEATANGGRMLVYGLGLLIMIPACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQ 96
            |...|.|.|   .||..|     .:|..||..|...|.::|....|||.:.||.:::.|||.:.|
Mouse    26 PAGAARGAR---GGLPEL-----SSAAKHEDSLFRDLFEDYEKWVRPVEHLSDKIKIKFGLAISQ 82

  Fly    97 IIDVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTY 161
            ::||||||||:.||:|||.||.|:.||||..::||::.:|:|...||.||::::::||..|:|.
Mouse    83 LVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKIIRVPSDSLWIPDIVLFDNADGRFEGA- 146

  Fly   162 ATNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDIS 226
            :|..|||.||:..:..|..:||:|.||:|:||||.|.|.||||||||||.|:|:.|:|: ..|.:
Mouse   147 STKTVVRYNGTVTWTQPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQ-DVDRT 210

  Fly   227 SFITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFT 291
            .|..||||:::...|.:.....:||..|.  ||::.:|:|..|:|...||:||:.::.:.::.|.
Mouse   211 DFFDNGEWEIMSAMGSKGNRTDSCCWYPC--ITYSFVIKRLPLFYTLFLIIPCIGLSFLTVVVFY 273

  Fly   292 LPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYH 356
            ||.:.|||:||..::|:||||||.::.|.:|::|..:||:|.|....|..|..|::.|:..:|.|
Mouse   274 LPSNEGEKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIH 338

  Fly   357 HRNPDTHE-MSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKER 420
            ||:..||. |:.|:|.|||:.||.:|.|:
Mouse   339 HRSSSTHNAMAPWVRKIFLHKLPKLLCMR------------------------------------ 367

  Fly   421 SSKSLLANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGRLHEAIS 485
                                       .|...|:........||        ||.....|..|:.
Mouse   368 ---------------------------SHADRYFTQREEAEKDG--------GPKSRNTLEAALD 397

  Fly   486 HTCLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLA- 549
              |               :|:||..:.||::..::..||||.|.|:||:.|..|.|.:||.||.
Mouse   398 --C---------------IRYITRHVVKENDVREVVEDWKFIAQVLDRMFLWTFLLVSIIGTLGL 445

  Fly   550 ---VLFSAPHFIV 559
               |::...:.||
Mouse   446 FVPVIYKWANIIV 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	168/489 (34%)
		Neur_chan_LBD	61..268	CDD:280998	92/206 (45%)
		Neur_chan_memb	275..552	CDD:280999	76/281 (27%)
Chrna5	NP_001360830.1	LGIC_ECD	45..251	CDD:355788	93/209 (44%)
		Neur_chan_memb	257..445	CDD:367256	75/275 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910