Protein Alignment nAChRalpha7 and Chrna3

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_660111.3
• Gene: Chrna3 / 110834
• MGIID: 87887
• Length: 499
• Species: Mus musculus
• Alignment Length: 532
• Identity: 192/532 - (36%)
• Similarity: 299/532 - (56%)
• Gaps: 48/532 - (9%)

  Fly    26 PQPHSLPEATANGGRMLVYGLGLLIMIPACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSF 90
            |.|.|:        .|||     |:::|..:|...|.||...|.::||.:.|||.|.|.|:.:.|
Mouse     7 PPPLSM--------LMLV-----LMLLPVASASEAEHRLFQYLFEDYNEIIRPVANVSHPVIIQF 58

  Fly    91 GLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADE 155
            .:::.|::.|||.||::.||:|||..|||..|:|..|::.||..:|:|..::||||:::||:||.
Mouse    59 EVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNADG 123

  Fly   156 GFDGTYATNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDE 220
            .|.....|..:::..|...::||.||||:||||:|:||||.|.|.||||||:||..::||.|..
Mouse   124 DFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIG- 187

  Fly   221 AGGDISSFITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASM 285
            :..::..:..:|||.::..||.::||.||||.|.|.|||:::.|||..|:|..|||:||:||:.:
Mouse   188 SSMNLKDYWESGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLISFL 252

  Fly   286 ALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTI 350
            .:|.|.||.|.|||::|.:::||||||||.::.||:|:||..:||:|.|....|..|..|:|.|:
Mouse   253 TVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITV 317

  Fly   351 LILNYHHRNPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNV 415
            .:||.|:|.|.||.|..|::.:||..||.::.|.||.....:.|...:...:        ::.|:
Mouse   318 FVLNVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRPTSTEEDAPKTRNFYGA--------ELSNL 374

  Fly   416 ELKERSSKSLLANVLDIDDDF--RCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDG 478
            ....|:............|..  .|:||....:     .:...:.|.....||..|
Mouse   375 NCFSRADSKSCKEGYPCQDGTCGYCHHRRVKIS-----NFSANLTRSSSSESVDAV--------- 425

  Fly   479 RLHEAISHTCLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFT 543
                 :|.:.|:.    |:...::.:::|.|.:|.::...:|..|||:.|||:||:.|.:|.|..
Mouse   426 -----LSLSALSP----EIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILVC 481

  Fly   544 IIATLAVLFSAP 555
            |:.| |.||..|
Mouse   482 ILGT-AGLFLQP 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	178/490 (36%)
		Neur_chan_LBD	61..268	CDD:280998	92/206 (45%)
		Neur_chan_memb	275..552	CDD:280999	85/278 (31%)
Chrna3	NP_660111.3	LIC	24..490	CDD:273305	182/498 (37%)
		LGIC_ECD_nAChR_A3	29..235	CDD:349817	92/206 (45%)
		Cys-loop	153..167	CDD:349817	10/13 (77%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910