DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha7 and chrna8

DIOPT Version :9

Sequence 1:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_021329572.1	Gene:	chrna8 / 100537531	ZFINID:	ZDB-GENE-090313-161	Length:	516	Species:	Danio rerio

Alignment Length:	527	Identity:	251/527 - (47%)
Similarity:	338/527 - (64%)	Gaps:	45/527 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LGLLIMIPAC----AAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQL 106
            ||:.|....|    ..|.::::|...|::|||.|||||:|:|.|:.:..||||:||||||||||:
Zfish    13 LGIFIWTSFCIKGSLQGEYQRKLYKELMENYNRLERPVLNDSAPIVVELGLTLLQIIDVDEKNQV 77

  Fly   107 LITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNG 171
            ||||.||:|.|.|:.|.||...:.||:.||.|.:::|.||:|:||||||.||.|:.|||:|..:|
Zfish    78 LITNAWLQLGWTDVYLSWNPDNYPGVQTLRFPSNQIWTPDILLYNSADERFDATFHTNVLVNASG 142

  Fly   172 SCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGEWDL 236
            :|.|:||||.||||.||:.|||||.|:|::||||||::|:.||||:|   ..|||::|.||||||
Zfish   143 ACQYIPPGILKSTCYIDVRWFPFDIQKCDLKFGSWTHNGWLLDLQMQ---AVDISTYIPNGEWDL 204

  Fly   237 LGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLS 301
            :||||||||:||.||.|||.|:||.:.:||:||||..||::|||||:.:|||.|.||.|||||:|
Zfish   205 VGVPGKRNELYYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISGLALLVFLLPADSGEKIS 269

  Fly   302 LGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMS 366
            ||:|:|||||||:.:|||.||||||:|||:..||...|.:|..|||.|:|:|.:||.:|...:|.
Zfish   270 LGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMMIVGLSVVVTVLVLQFHHHDPQGGKMP 334

  Fly   367 EWIRVIFLYWLPCILRMQRPGQ-----VGYECPPPPSSSSSSASGEKKQQIQNVELKERSSKSLL 426
            .|:|||.|.|....|||::||:     ..|:..|...:|:||        ||...:..:.|.:
Zfish   335 RWVRVILLNWCAWFLRMKKPGEERKANFKYDQSPAHHASASS--------IQMGVMPGQPSST-- 389

  Fly   427 ANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGP-----VGPAGPVVDGRLHEAISH 486
                            .|.|..|...|:.  |...|.....|     |..:|..|.|..:|....
Zfish   390 ----------------NSTTNGHMNLYFG--YHSIDSACCPPSSDSGVSCSGGRVGGSPNEEQRE 436

  Fly   487 TCLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVL 551
            .....:.|.|:..||.|:.:|.::.:.:||...|..:|||||.|||||||:.|:||:||.|..:|
Zfish   437 GVRMFAGEPEIHRILAEVMYIAQRFRDQDEAEAICSEWKFAAAVVDRLCLVAFSLFSIICTFTIL 501

  Fly   552 FSAPHFI 558
            .|||:||
Zfish   502 MSAPNFI 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	239/498 (48%)
		Neur_chan_LBD	61..268	CDD:280998	123/206 (60%)
		Neur_chan_memb	275..552	CDD:280999	112/286 (39%)
chrna8	XP_021329572.1	Neur_chan_LBD	12..504	CDD:332142	246/521 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	288	1.000	Domainoid score	I1532
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	510	1.000	Inparanoid score	I1280
OMA	1	1.010	-	-		QHG45242
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	1	1.000	-	-		mtm6506
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980